Association Between Residential Greenness and Cardiovascular Disease Risk

dc.contributor.authorYeager, Ray
dc.contributor.authorRiggs, Daniel W.
dc.contributor.authorDeJarnett, Natasha
dc.contributor.authorTollerud, David J.
dc.contributor.authorWilson, Jeffrey S.
dc.contributor.authorConklin, Daniel J.
dc.contributor.authorO'Toole, Timothy E.
dc.contributor.authorMcCracken, James
dc.contributor.authorLorkiewicz, Pawel
dc.contributor.authorXie, Zhengzhi
dc.contributor.authorZafar, Nagma
dc.contributor.authorKrishnasamy, Sathya S.
dc.contributor.authorSrivastava, Sanjay
dc.contributor.authorFinch, Jordan
dc.contributor.authorKeith, Rachel J.
dc.contributor.authorDeFilippis, Andrew
dc.contributor.authorRai, Shesh N.
dc.contributor.authorLiu, Gilbert
dc.contributor.authorBhatnagar, Aruni
dc.contributor.departmentGeography, School of Liberal Artsen_US
dc.date.accessioned2019-08-28T13:43:27Z
dc.date.available2019-08-28T13:43:27Z
dc.date.issued2018-12-18
dc.description.abstractBackground Exposure to green vegetation has been linked to positive health, but the pathophysiological processes affected by exposure to vegetation remain unclear. To study the relationship between greenness and cardiovascular disease, we examined the association between residential greenness and biomarkers of cardiovascular injury and disease risk in susceptible individuals. Methods and Results In this cross-sectional study of 408 individuals recruited from a preventive cardiology clinic, we measured biomarkers of cardiovascular injury and risk in participant blood and urine. We estimated greenness from satellite-derived normalized difference vegetation index ( NDVI ) in zones with radii of 250 m and 1 km surrounding the participants' residences. We used generalized estimating equations to examine associations between greenness and cardiovascular disease biomarkers. We adjusted for residential clustering, demographic, clinical, and environmental variables. In fully adjusted models, contemporaneous NDVI within 250 m of participant residence was inversely associated with urinary levels of epinephrine (-6.9%; 95% confidence interval, -11.5, -2.0/0.1 NDVI ) and F2-isoprostane (-9.0%; 95% confidence interval, -15.1, -2.5/0.1 NDVI ). We found stronger associations between NDVI and urinary epinephrine in women, those not on β-blockers, and those who had not previously experienced a myocardial infarction. Of the 15 subtypes of circulating angiogenic cells examined, 11 were inversely associated (8.0-15.6% decrease/0.1 NDVI ), whereas 2 were positively associated (37.6-45.8% increase/0.1 NDVI ) with contemporaneous NDVI . Conclusions Independent of age, sex, race, smoking status, neighborhood deprivation, statin use, and roadway exposure, residential greenness is associated with lower levels of sympathetic activation, reduced oxidative stress, and higher angiogenic capacity.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationYeager, R., Riggs, D. W., DeJarnett, N., Tollerud, D. J., Wilson, J., Conklin, D. J., … Bhatnagar, A. (2018). Association Between Residential Greenness and Cardiovascular Disease Risk. Journal of the American Heart Association, 7(24), e009117. doi:10.1161/JAHA.118.009117en_US
dc.identifier.urihttps://hdl.handle.net/1805/20644
dc.language.isoen_USen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.isversionof10.1161/JAHA.118.009117en_US
dc.relation.journalJournal of the American Heart Associationen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.sourcePMCen_US
dc.subjectCardiovascular disease risk factorsen_US
dc.subjectCatecholamineen_US
dc.subjectEndothelial progenitor cellsen_US
dc.subjectEnvironmenten_US
dc.subjectGreennessen_US
dc.subjectNormalized difference vegetation indexen_US
dc.subjectOxidative stressen_US
dc.titleAssociation Between Residential Greenness and Cardiovascular Disease Risken_US
dc.typeArticleen_US
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