Sleep-disordered Breathing in Pregnancy and after Delivery: Associations with Cardiometabolic Health
dc.contributor.author | Facco, Francesca L. | |
dc.contributor.author | Redline, Susan | |
dc.contributor.author | Hunter, Shannon M. | |
dc.contributor.author | Zee, Phyllis C. | |
dc.contributor.author | Grobman, William A. | |
dc.contributor.author | Silver, Robert M. | |
dc.contributor.author | Louis, Judette M. | |
dc.contributor.author | Pien, Grace W. | |
dc.contributor.author | Mercer, Brian | |
dc.contributor.author | Chung, Judith H. | |
dc.contributor.author | Merz, C. Noel Bairey | |
dc.contributor.author | Haas, David M. | |
dc.contributor.author | Nhan-Chang, Chia-Ling | |
dc.contributor.author | Simhan, Hyagriv N. | |
dc.contributor.author | Schubert, Frank P. | |
dc.contributor.author | Parry, Samuel | |
dc.contributor.author | Reddy, Uma | |
dc.contributor.author | Saade, George R. | |
dc.contributor.author | Hoffman, Matthew K. | |
dc.contributor.author | Levine, Lisa D. | |
dc.contributor.author | Wapner, Ronald J. | |
dc.contributor.author | Catov, Janet M. | |
dc.contributor.author | Parker, Corette B. | |
dc.contributor.department | Obstetrics and Gynecology, School of Medicine | |
dc.date.accessioned | 2024-05-15T09:55:40Z | |
dc.date.available | 2024-05-15T09:55:40Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Rationale: Knowledge gaps exist regarding health implications of sleep-disordered breathing (SDB) identified in pregnancy and/or after delivery. Objectives: To determine whether SDB in pregnancy and/or after delivery is associated with hypertension (HTN) and metabolic syndrome (MS). Methods: nuMoM2b-HHS (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be Heart Health Study) (N = 4,508) followed participants initially recruited during their first pregnancy. Participants returned for a visit 2-7 years after pregnancy. This study examined a subgroup who underwent SDB assessments during their first pregnancy (n = 1,964) and a repeat SDB assessment after delivery (n = 1,222). Two SDB definitions were considered: 1) apnea-hypopnea index (AHI) ⩾ 5 and 2) oxygen desaturation index (ODI) ⩾ 5. Associations between SDB and incident HTN and MS were evaluated with adjusted risk ratios (aRRs). Measurements and Main Results: The aRR for MS given an AHI ⩾ 5 during pregnancy was 1.44 (95% confidence interval [CI], 1.08-1.93), but no association with HTN was found. ODI ⩾ 5 in pregnancy was associated with both an increased risk for HTN (aRR, 2.02; 95% CI, 1.30-3.14) and MS (aRR, 1.53; 95% CI, 1.19-1.97). Participants with an AHI ⩾ 5 in pregnancy that persisted after delivery were at higher risk for both HTN (aRR, 3.77; 95% CI, 1.84-7.73) and MS (aRR, 2.46; 95% CI, 1.59-3.76). Similar associations were observed for persistent ODI ⩾ 5 after delivery. Conclusions: An AHI ⩾ 5 in pregnancy was associated with an increased risk of MS. An ODI ⩾ 5 in pregnancy was significantly associated with both HTN and MS. Participants with persistent elevations in AHI and ODI during pregnancy and at 2-7 years after delivery were at the highest risk for HTN and MS. | |
dc.eprint.version | Final published version | |
dc.identifier.citation | Facco FL, Redline S, Hunter SM, et al. Sleep-disordered Breathing in Pregnancy and after Delivery: Associations with Cardiometabolic Health. Am J Respir Crit Care Med. 2022;205(10):1202-1213. doi:10.1164/rccm.202104-0971OC | |
dc.identifier.uri | https://hdl.handle.net/1805/40753 | |
dc.language.iso | en_US | |
dc.publisher | American Thoracic Society | |
dc.relation.isversionof | 10.1164/rccm.202104-0971OC | |
dc.relation.journal | American Journal of Respiratory and Critical Care Medicine | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Sleep-disordered breathing | |
dc.subject | Pregnancy | |
dc.subject | Postpartum | |
dc.subject | Cardiometabolic health | |
dc.subject | Hypertension | |
dc.title | Sleep-disordered Breathing in Pregnancy and after Delivery: Associations with Cardiometabolic Health | |
dc.type | Article | |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872809/ |