Effect of Delirium on Physical Function in Noncardiac Thoracic Surgery Patients

dc.contributor.authorKhan, Sikandar H.
dc.contributor.authorXu, Chenjia
dc.contributor.authorWang, Sophia
dc.contributor.authorGao, Sujuan
dc.contributor.authorLasiter, Sue
dc.contributor.authorKesler, Kenneth
dc.contributor.authorKhan, Babar A.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2022-06-21T13:11:28Z
dc.date.available2022-06-21T13:11:28Z
dc.date.issued2020-03
dc.description.abstractBackground: The effect of delirium on physical function in patients undergoing noncardiac thoracic surgery has not been well described and may differ from that in other surgical populations. Objective: To determine the effects of delirium on muscle strength and functional independence. The primary end point was change in Medical Research Council sum score (MRC-SS) by delirium status. Methods: A secondary analysis of data from a clinical trial involving English-speaking adults aged 18 years or older who were undergoing major noncardiac thoracic surgery. Exclusion criteria were history of schizophrenia, Parkinson disease, dementia, alcohol abuse, or neuroleptic malignant syndrome; haloperidol allergy; being pregnant or nursing; QT prolongation; and taking levodopa or cholinesterase inhibitors. Delirium was assessed twice daily using the Confusion Assessment Method for the Intensive Care Unit. Preoperatively and postoperatively, muscle strength was assessed using the modified MRC-SS and functional independence was assessed using the Katz scale of activities of daily living. Changes in MRC-SS and Katz score by delirium status were analyzed using the Fisher exact test. Results: Seventy-three patients were included in the analysis. Median (interquartile range) MRC-SS and Katz score before surgery did not differ significantly between patients without and with delirium (MRC-SS: 30 [30-30] vs 30 [30-30], P > .99; Katz score: 6 [6-6] vs 6 [6-6], P = .63). The percentage of patients with a change in MRC-SS was similar in patients without and with delirium (17% vs 13%, respectively; P > .99). More patients in the delirium group had a change in Katz score (13% vs 0%, P = .04). Conclusions: Postoperative delirium was not associated with change in muscle strength. Follow-up studies using other muscle measures may be needed.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationKhan SH, Xu C, Wang S, et al. Effect of Delirium on Physical Function in Noncardiac Thoracic Surgery Patients. Am J Crit Care. 2020;29(2):e39-e43. doi:10.4037/ajcc2020579en_US
dc.identifier.urihttps://hdl.handle.net/1805/29385
dc.language.isoen_USen_US
dc.publisherAmerican Association of Critical-Care Nursesen_US
dc.relation.isversionof10.4037/ajcc2020579en_US
dc.relation.journalAmerican Journal of Critical Careen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectDeliriumen_US
dc.subjectDisability evaluationen_US
dc.subjectIntensive Care Unitsen_US
dc.subjectMuscle strengthen_US
dc.subjectPostoperative complicationsen_US
dc.subjectThoracic surgical proceduresen_US
dc.titleEffect of Delirium on Physical Function in Noncardiac Thoracic Surgery Patientsen_US
dc.typeArticleen_US
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