Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes

Simple item page
dc.contributor.authorRomanoski, Casey E.
dc.contributor.authorQi, Xinshuai
dc.contributor.authorSangam, Shreya
dc.contributor.authorVanderpool, Rebecca R.
dc.contributor.authorStearman, Robert S.
dc.contributor.authorConklin, Austin
dc.contributor.authorGonzalez-Garay, Manuel
dc.contributor.authorRischard, Franz
dc.contributor.authorAyon, Ramon J.
dc.contributor.authorWang, Jian
dc.contributor.authorSimonson, Tatum
dc.contributor.authorBabicheva, Aleksandra
dc.contributor.authorShi, Yinan
dc.contributor.authorTang, Haiyang
dc.contributor.authorMakino, Ayako
dc.contributor.authorKanthi, Yogendra
dc.contributor.authorGeraci, Mark W.
dc.contributor.authorGarcia, Joe G.N.
dc.contributor.authorYuan, Jason X.-J.
dc.contributor.authorDesai, Ankit A.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2022-04-22T15:47:04Z
dc.date.available2022-04-22T15:47:04Z
dc.date.issued2020-12-07
dc.description.abstractUsing RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationRomanoski CE, Qi X, Sangam S, et al. Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes. Pulm Circ. 2020;10(4):2045894020968531. Published 2020 Dec 7. doi:10.1177/2045894020968531en_US
dc.identifier.urihttps://hdl.handle.net/1805/28708
dc.language.isoen_USen_US
dc.publisherSageen_US
dc.relation.isversionof10.1177/2045894020968531en_US
dc.relation.journalPulmonary Circulationen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.sourcePMCen_US
dc.subjectPBMCen_US
dc.subjectRNAseqen_US
dc.subjectPulmonary arterial hypertensionen_US
dc.subjectTranscriptome profilingen_US
dc.titleTranscriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genesen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
10.1177_2045894020968531.pdf
Size:
482.93 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Policy Articles
Department of Medicine Works