Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes

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dc.contributor.authorRomanoski, Casey E.
dc.contributor.authorQi, Xinshuai
dc.contributor.authorSangam, Shreya
dc.contributor.authorVanderpool, Rebecca R.
dc.contributor.authorStearman, Robert S.
dc.contributor.authorConklin, Austin
dc.contributor.authorGonzalez-Garay, Manuel
dc.contributor.authorRischard, Franz
dc.contributor.authorAyon, Ramon J.
dc.contributor.authorWang, Jian
dc.contributor.authorSimonson, Tatum
dc.contributor.authorBabicheva, Aleksandra
dc.contributor.authorShi, Yinan
dc.contributor.authorTang, Haiyang
dc.contributor.authorMakino, Ayako
dc.contributor.authorKanthi, Yogendra
dc.contributor.authorGeraci, Mark W.
dc.contributor.authorGarcia, Joe G.N.
dc.contributor.authorYuan, Jason X.-J.
dc.contributor.authorDesai, Ankit A.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2022-04-22T15:47:04Z
dc.date.available2022-04-22T15:47:04Z
dc.date.issued2020-12-07
dc.description.abstractUsing RNAseq, we identified a 61 gene-based circulating transcriptomic profile most correlated with four indices of pulmonary arterial hypertension severity. In an independent dataset, 13/61 (21%) genes were differentially expressed in lung tissues of pulmonary arterial hypertension cases versus controls, highlighting potentially novel candidate genes involved in pulmonary arterial hypertension development.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationRomanoski CE, Qi X, Sangam S, et al. Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes. Pulm Circ. 2020;10(4):2045894020968531. Published 2020 Dec 7. doi:10.1177/2045894020968531en_US
dc.identifier.urihttps://hdl.handle.net/1805/28708
dc.language.isoen_USen_US
dc.publisherSageen_US
dc.relation.isversionof10.1177/2045894020968531en_US
dc.relation.journalPulmonary Circulationen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0*
dc.sourcePMCen_US
dc.subjectPBMCen_US
dc.subjectRNAseqen_US
dc.subjectPulmonary arterial hypertensionen_US
dc.subjectTranscriptome profilingen_US
dc.titleTranscriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genesen_US
dc.typeArticleen_US
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