FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing
dc.contributor.author | Du, Jianguang | |
dc.contributor.author | Wang, Qun | |
dc.contributor.author | Ziegler, Steven F. | |
dc.contributor.author | Zhou, Baohua | |
dc.contributor.department | Microbiology and Immunology, School of Medicine | en_US |
dc.date.accessioned | 2019-08-27T13:07:48Z | |
dc.date.available | 2019-08-27T13:07:48Z | |
dc.date.issued | 2018-06-29 | |
dc.description.abstract | FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes. We report here that FOXP3 associates with heterogeneous nuclear ribonucleoprotein (hnRNP) F through the exon 2-encoded region of FOXP3 and the second quasi-RNA recognition motif (qRRM) of hnRNPF. FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing. Furthermore, overexpression of mouse hnRNPF in in vitro-differentiated regulatory T cells (Tregs) reduced their suppressive function. Thus, our studies identify a novel mechanism by which FOXP3 regulates mRNA alternative splicing to modulate the function of regulatory T cells. | en_US |
dc.identifier.citation | Du, J., Wang, Q., Ziegler, S. F., & Zhou, B. (2018). FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing. The Journal of biological chemistry, 293(26), 10235–10244. doi:10.1074/jbc.RA117.001349 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/20594 | |
dc.language.iso | en_US | en_US |
dc.publisher | American Society for Biochemistry and Molecular Biology | en_US |
dc.relation.isversionof | 10.1074/jbc.RA117.001349 | en_US |
dc.relation.journal | The Journal of Biological Chemistry | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Forkhead box P3 (FOXP3) | en_US |
dc.subject | Heterogeneous nuclear ribonucleoprotein (hnRNP) | en_US |
dc.subject | RNA splicing | en_US |
dc.subject | RNA-protein interaction | en_US |
dc.subject | Immunology | en_US |
dc.subject | Treg | en_US |
dc.subject | Immunosuppression | en_US |
dc.subject | Alternative splicing | en_US |
dc.title | FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing | en_US |
dc.type | Article | en_US |