Web-based Cognitive-behavioral Intervention for Pain in Pediatric Acute Recurrent and Chronic Pancreatitis: Protocol of a Multicenter Randomized Controlled Trial from the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC)
dc.contributor.author | Palermo, Tonya M. | |
dc.contributor.author | Murray, Caitlin | |
dc.contributor.author | Aalfs, Homer | |
dc.contributor.author | Abu-El-Haija, Maisam | |
dc.contributor.author | Barth, Bradley | |
dc.contributor.author | Bellin, Melena D. | |
dc.contributor.author | Ellery, Kate | |
dc.contributor.author | Fishman, Douglas S. | |
dc.contributor.author | Gariepy, Cheryl E. | |
dc.contributor.author | Giefer, Matthew J. | |
dc.contributor.author | Goday, Praveen | |
dc.contributor.author | Gonska, Tanja | |
dc.contributor.author | Heyman, Melvin B. | |
dc.contributor.author | Husain, Sohail Z. | |
dc.contributor.author | Lin, Tom K. | |
dc.contributor.author | Liu, Quin Y. | |
dc.contributor.author | Mascarenhas, Maria R. | |
dc.contributor.author | Maqbool, Asim | |
dc.contributor.author | McFerron, Brian | |
dc.contributor.author | Morinville, Veronique D. | |
dc.contributor.author | Nathan, Jaimie D. | |
dc.contributor.author | Ooi, Chee Y. | |
dc.contributor.author | Perito, Emily R. | |
dc.contributor.author | Pohl, John F. | |
dc.contributor.author | Schwarzenberg, Sarah Jane | |
dc.contributor.author | Sellers, Zachary M. | |
dc.contributor.author | Serrano, Jose | |
dc.contributor.author | Shah, Uzma | |
dc.contributor.author | Troendle, David | |
dc.contributor.author | Zheng, Yuhua | |
dc.contributor.author | Yuan, Ying | |
dc.contributor.author | Lowe, Mark | |
dc.contributor.author | Uc, Aliye | |
dc.contributor.department | Pediatrics, School of Medicine | en_US |
dc.date.accessioned | 2020-01-31T19:26:39Z | |
dc.date.available | 2020-01-31T19:26:39Z | |
dc.date.issued | 2020-01 | |
dc.description.abstract | Introduction Abdominal pain is common and is associated with high disease burden and health care costs in pediatric acute recurrent and chronic pancreatitis (ARP/CP). Despite the strong central component of pain in ARP/CP and the efficacy of psychological therapies for other centralized pain syndromes, no studies have evaluated psychological pain interventions in children with ARP/CP. The current trial seeks to 1) evaluate the efficacy of a psychological pain intervention for pediatric ARP/CP, and 2) examine baseline patient-specific genetic, clinical, and psychosocial characteristics that may predict or moderate treatment response. Methods This single-blinded randomized placebo-controlled multicenter trial aims to enroll 260 youth (ages 10–18) with ARP/CP and their parents from twenty-one INSPPIRE (INternational Study Group of Pediatric Pancreatitis: In search for a cuRE) centers. Participants will be randomly assigned to either a web-based cognitive behavioral pain management intervention (Web-based Management of Adolescent Pain Chronic Pancreatitis; WebMAP; N = 130) or to a web-based pain education program (WebED; N = 130). Assessments will be completed at baseline (T1), immediately after completion of the intervention (T2) and at 6 months post-intervention (T3). The primary study outcome is abdominal pain severity. Secondary outcomes include pain-related disability, pain interference, health-related quality of life, emotional distress, impact of pain, opioid use, and healthcare utilization. Conclusions This is the first clinical trial to evaluate the efficacy of a psychological pain intervention for children with CP for reduction of abdominal pain and improvement of health-related quality of life. Findings will inform delivery of web-based pain management and potentially identify patient-specific biological and psychosocial factors associated with favorable response to therapy. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Palermo, T. M., Murray, C., Aalfs, H., Abu-El-Haija, M., Barth, B., Bellin, M. D., … Uc, A. (2019). Web-based cognitive-behavioral intervention for pain in pediatric acute recurrent and chronic pancreatitis: Protocol of a multicenter randomized controlled trial from the study of chronic pancreatitis, diabetes and pancreatic cancer (CPDPC). Contemporary Clinical Trials, 88, 105898. https://doi.org/10.1016/j.cct.2019.105898 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/21962 | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.cct.2019.105898 | en_US |
dc.relation.journal | Contemporary Clinical Trials | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Publisher | en_US |
dc.subject | children | en_US |
dc.subject | chronic pancreatitis | en_US |
dc.subject | acute recurrent pancreatitis | en_US |
dc.title | Web-based Cognitive-behavioral Intervention for Pain in Pediatric Acute Recurrent and Chronic Pancreatitis: Protocol of a Multicenter Randomized Controlled Trial from the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC) | en_US |
dc.type | Article | en_US |