Genetics of perioperative pain management
dc.contributor.author | Packiasabapathy, Senthil | |
dc.contributor.author | Horn, Nicole | |
dc.contributor.author | Sadhasivam, Senthilkumar | |
dc.contributor.department | Anesthesia, School of Medicine | en_US |
dc.date.accessioned | 2020-02-03T14:19:51Z | |
dc.date.available | 2020-02-03T14:19:51Z | |
dc.date.issued | 2018-12 | |
dc.description.abstract | PURPOSE OF REVIEW: The current review will discuss the current literature on genetics of pain and analgesia, with special emphasis on perioperative setting. We will also discuss pharmacogenetics-based management guidelines, current clinical status and future perspectives. RECENT FINDINGS: Recent literature suggests that the interindividual variability in pain and postoperative analgesic response is at least in part because of one's genetic make-up. Some of the well characterized polymorphisms that are associated with surgical pain and opioid-related postoperative adverse outcomes are described in catechol-O-methyl transferase, CYP2D6 and μ-opioid receptor (OPRM1), ATP-binding cassette subfamily B member 1, ABCC3, organic cation transporter 1 genes. Clinical Pharmacogenetics Implementation Consortium has put forth recommendations on CYP2D6 genotype-based opioid selection and dosing. The list of drug-gene pairs studied continue to expand. SUMMARY: Pharmacogenetic approach marks the dawn of personalized pain medicine both in perioperative and chronic pain settings. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Packiasabapathy, S., Horn, N., & Sadhasivam, S. (2018). Genetics of perioperative pain management. Current opinion in anaesthesiology, 31(6), 749–755. doi:10.1097/ACO.0000000000000660 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/21972 | |
dc.language.iso | en_US | en_US |
dc.publisher | Lippincott, Williams & Wilkins | en_US |
dc.relation.isversionof | 10.1097/ACO.0000000000000660 | en_US |
dc.relation.journal | Current Opinion in Anaesthesiology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Analgesia | en_US |
dc.subject | Genetics | en_US |
dc.subject | Opioids | en_US |
dc.subject | Pain | en_US |
dc.subject | Personalized analgesia | en_US |
dc.subject | Pharmacodynamics | en_US |
dc.subject | Pharmacogenomics | en_US |
dc.subject | Pharmacokinetics | en_US |
dc.subject | Postoperative pain | en_US |
dc.subject | Respiratory depression | en_US |
dc.title | Genetics of perioperative pain management | en_US |
dc.type | Article | en_US |