CB1 Receptors Regulate Alcohol-Seeking Behavior and Alcohol Self-administration of Female Alcohol-Preferring (P) Rats
dc.contributor.author | Getachew, Bruk | |
dc.contributor.author | Hauser, Sheketha R. | |
dc.contributor.author | Dhaher, Ronnie | |
dc.contributor.author | Bell, Richard L. | |
dc.contributor.author | Oster, Scott M. | |
dc.contributor.author | McBride, William J. | |
dc.contributor.author | Rodd, Zachary A. | |
dc.contributor.department | Department of Psychiatry, IU School of Medicine | en_US |
dc.date.accessioned | 2016-02-08T21:51:22Z | |
dc.date.available | 2016-02-08T21:51:22Z | |
dc.date.issued | 2011-02 | |
dc.description.abstract | Rationale The endogenous cannabinoid (CB) system mediates a number of behaviors associated with drug-seeking and drug self-administration. In this study the effects of CB1 receptor manipulations on operant ethanol (EtOH) responding during EtOH-seeking, EtOH- relapse as well as on-going EtOH self-administration were determined. Methods Alcohol-preferring (P) rats were trained in 2-lever operant chambers to self-administer 15% EtOH (v/v) and water on a concurrent fixed-ratio 5 – fixed-ratio 1 (FR5-FR1) schedule of reinforcement in daily 1-hr sessions. After 10 weeks, rats underwent 7 extinction sessions, followed by 2 weeks in their home cages without access to EtOH or operant chambers. Rats were then returned to the operant chambers for testing of EtOH-seeking behavior (no EtOH present) for 4 sessions. After a week in their home cages following the EtOH-seeking test, rats were returned to the operant chambers with access to EtOH and water (relapse). Rats were then maintained in the operant chambers for daily 1-hr sessions with access to 15% EtOH and water for several weeks. Results The CB1 receptor antagonist (SR141716A), at doses of 1 and 2 mg/kg, i.p. reduced EtOH-seeking and transiently reduced EtOH self-administration during relapse and maintenance. Conversely, treatment with the CB1 receptor agonist CP, 55-940, at doses of 1 and 10 μg/kg i.p., increased EtOH-seeking and EtOH self-administration during relapse. Conclusions The results of this study demonstrate that activation of CB1 receptors are involved in regulating EtOH-seeking as well as the reinforcing effects of EtOH under relapse and on-going self-administration conditions. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Getachew, B., Hauser, S. R., Dhaher, R., Bell, R. L., Oster, S. M., McBride, W. J., & Rodd, Z. A. (2011). CB1 Receptors Regulate Alcohol-Seeking Behavior and Alcohol Self-administration of Female Alcohol-Preferring (P) Rats. Pharmacology, Biochemistry, and Behavior, 97(4), 669–675. http://doi.org/10.1016/j.pbb.2010.11.006 | en_US |
dc.identifier.issn | 0091-3057 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/8277 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.pbb.2010.11.006 | en_US |
dc.relation.journal | Pharmacology, biochemistry, and behavior | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Ethanol | en_US |
dc.subject | administration & dosage | en_US |
dc.subject | Motivation | en_US |
dc.subject | Receptor, Cannabinoid, CB1 | en_US |
dc.subject | physiology | en_US |
dc.title | CB1 Receptors Regulate Alcohol-Seeking Behavior and Alcohol Self-administration of Female Alcohol-Preferring (P) Rats | en_US |
dc.type | Article | en_US |