Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection

dc.contributor.authorRoberts, W. Eugene
dc.contributor.authorMangum, Jonathan E.
dc.contributor.authorSchneider, Paul M.
dc.contributor.departmentOrthodontics and Oral Facial Genetics, School of Dentistry
dc.date.accessioned2024-05-01T15:35:42Z
dc.date.available2024-05-01T15:35:42Z
dc.date.issued2022
dc.description.abstractPurpose of review: Compare noninfectious (part I) to infectious (part II) demineralization of bones and teeth. Evaluate similarities and differences in the expression of hard tissue degradation for the two most common chronic demineralization diseases: osteoporosis and dental caries. Recent findings: The physiology of demineralization is similar for the sterile skeleton compared to the septic dentition. Superimposing the pathologic variable of infection reveals a unique pathophysiology for dental caries. Mineralized tissues are compromised by microdamage, demineralization, and infection. Osseous tissues remodel (turnover) to maintain structural integrity, but the heavily loaded dentition does not turnover so it is ultimately at risk of collapse. A carious tooth is a potential vector for periapical infection that may be life-threatening. Insipient caries is initiated as a subsurface decalcification in enamel that is not detectable until a depth of ~400μm when it becomes visible as a white spot. Reliable detection and remineralization of invisible caries would advance cost-effective wellness worldwide.
dc.eprint.versionFinal published version
dc.identifier.citationRoberts WE, Mangum JE, Schneider PM. Pathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection. Curr Osteoporos Rep. 2022;20(1):106-119. doi:10.1007/s11914-022-00723-0
dc.identifier.urihttps://hdl.handle.net/1805/40407
dc.language.isoen_US
dc.publisherSpringer
dc.relation.isversionof10.1007/s11914-022-00723-0
dc.relation.journalCurrent Osteoporosis Reports
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.sourcePMC
dc.subjectCost-effective
dc.subjectHealthcare
dc.subjectWellness
dc.subjectDental caries
dc.subjectWhite spot lesion
dc.subjectRemineralization
dc.titlePathophysiology of Demineralization, Part II: Enamel White Spots, Cavitated Caries, and Bone Infection
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Roberts2022Pathophysiology-CCBY.pdf
Size:
713.25 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description: