The Impact of Advanced Glycation End Products on Bone Properties in Chronic Kidney Disease

dc.contributor.authorDamrath, John G.
dc.contributor.authorCreecy, Amy
dc.contributor.authorWallace, Joseph M.
dc.contributor.authorMoe, Sharon M.
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2023-08-02T12:33:09Z
dc.date.available2023-08-02T12:33:09Z
dc.date.issued2021
dc.description.abstractPurpose of review: Chronic kidney disease (CKD) affects over 15% of Americans and results in an increased risk of skeletal fractures and fracture-related mortality. However, there remain great challenges in estimating fracture risk in CKD patients, as conventional metrics such as bone density assess bone quantity without accounting for the material quality of the bone tissue. The purpose of this review is to highlight the detrimental effects of advanced glycation end products (AGEs) on the structural and mechanical properties of bone, and to demonstrate the importance of including bone quality when assessing fracture risk in CKD patients. Recent findings: Increased oxidative stress and inflammation drive the production of AGEs in CKD patients that form nonenzymatic crosslinks between type I collagen fibrils in the bone matrix. Nonenzymatic crosslinks stiffen and embrittle the bone, reducing its ability to absorb energy and resist fracture. Clinical measurement of AGEs is typically indirect and fails to distinguish the identity and properties of the various AGEs. Summary: Accounting for the impact of AGEs on the skeleton in CKD patients may improve our estimation of overall bone quality, fracture risk, and treatments to improve both bone quantity and quality by reducing AGEs in patients with CKD merit investigation in order to improve our understanding of the etiology of increased fracture risk.
dc.eprint.versionAuthor's manuscript
dc.identifier.citationDamrath JG, Creecy A, Wallace JM, Moe SM. The impact of advanced glycation end products on bone properties in chronic kidney disease. Curr Opin Nephrol Hypertens. 2021;30(4):411-417. doi:10.1097/MNH.0000000000000713
dc.identifier.urihttps://hdl.handle.net/1805/34676
dc.language.isoen_US
dc.publisherWolters Kluwer
dc.relation.isversionof10.1097/MNH.0000000000000713
dc.relation.journalCurrent Opinion in Nephrology and Hypertension
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectBone density
dc.subjectBone fractures
dc.subjectChronic renal insufficiency
dc.titleThe Impact of Advanced Glycation End Products on Bone Properties in Chronic Kidney Disease
dc.typeArticle
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