Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests
dc.contributor.author | Wakita, Mitsuru | |
dc.contributor.author | Idei, Mayumi | |
dc.contributor.author | Saito, Kaori | |
dc.contributor.author | Horiuchi, Yuki | |
dc.contributor.author | Yamatani, Kotoko | |
dc.contributor.author | Ishikawa, Suzuka | |
dc.contributor.author | Yamamoto, Takamasa | |
dc.contributor.author | Igawa, Gene | |
dc.contributor.author | Hinata, Masanobu | |
dc.contributor.author | Kadota, Katsuhiko | |
dc.contributor.author | Kurosawa, Taro | |
dc.contributor.author | Takahashi, Sho | |
dc.contributor.author | Saito, Takumi | |
dc.contributor.author | Misawa, Shigeki | |
dc.contributor.author | Akazawa, Chihiro | |
dc.contributor.author | Naito, Toshio | |
dc.contributor.author | Milda, Takashi | |
dc.contributor.author | Takahashi, Kazuhisa | |
dc.contributor.author | Ai, Tomohiko | |
dc.contributor.author | Tabe, Yoko | |
dc.contributor.department | Medicine, School of Medicine | en_US |
dc.date.accessioned | 2021-04-16T16:43:54Z | |
dc.date.available | 2021-04-16T16:43:54Z | |
dc.date.issued | 2021 | |
dc.description.abstract | We examined the usefulness of five COVID-19 antibody detection tests using 114 serum samples at various time points from 34 Japanese COVID-19 patients. We examined Elecsys Anti-SARS-CoV-2 from Roche, and four immunochromatography tests from Hangzhou Laihe Biotech, Artron Laboratories, Chil, and Nadal. In the first week after onset, Elecsys had 40% positivity in Group S (severe cases) but was negative in Group M (mild-moderate cases). The immunochromatography kits showed 40–60% and 0–8% positivity in Groups S and M, respectively. In the second week, Elecsys showed 75% and 50% positivity, and the immunochromatography tests showed 5–80% and 50–75% positivity in Groups S and M, respectively. After the third week, Elecsys showed 100% positivity in both groups. The immunochromatography kits showed 100% positivity in Group S. In Group M, positivity decreased to 50% for Chil and 75–89% for Artron and Lyher. Elecsys and immunochromatography kits had 91–100% specificity. Elecsys had comparable chronological change of cut-off index values in the two groups from the second week to the sixth week. The current SARS-CoV-2 antibody detection tests do not provide meaningful interpretation of severity and infection status. Its use might be limited to short-term epidemiological studies. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Wakita, M., Idei, M., Saito, K., Horiuchi, Y., Yamatani, K., Ishikawa, S., ... & Tabe, Y. (2021). Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests. Plos one, 16(2), e0246536. https://doi.org/10.1371/journal.pone.0246536 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/25664 | |
dc.language.iso | en | en_US |
dc.publisher | PloS | en_US |
dc.relation.isversionof | 10.1371/journal.pone.0246536 | en_US |
dc.relation.journal | PloS One | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | Publisher | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | antibody detection tests | en_US |
dc.title | Comparison of the clinical performance and usefulness of five SARS-CoV-2 antibody tests | en_US |
dc.type | Article | en_US |