Correlation of plasma and neuroimaging biomarkers in Alzheimer’s disease

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dc.contributor.authorBrickman, Adam M.
dc.contributor.authorManly, Jennifer J.
dc.contributor.authorHonig, Lawrence S.
dc.contributor.authorSanchez, Danurys
dc.contributor.authorReyes-Dumeyer, Dolly
dc.contributor.authorLantigua, Rafael A.
dc.contributor.authorVonsattel, Jean Paul
dc.contributor.authorTeich, Andrew F.
dc.contributor.authorKang, Min Suk
dc.contributor.authorDage, Jeffrey L.
dc.contributor.authorMayeux, Richard
dc.contributor.departmentNeurology, School of Medicineen_US
dc.date.accessioned2023-06-22T11:55:09Z
dc.date.available2023-06-22T11:55:09Z
dc.date.issued2022
dc.description.abstractBlood-based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were classified as biomarker positive (Ptau+) or negative (Ptau-) based on Ptau 181 and 217 concentrations and as cognitively impaired (Sym) or unimpaired (Asym). The four groups, Ptau-/Asym, Ptau+/Asym, Ptau-/Sym, and Ptau+/Sym, differed by age, APOE-4 allele frequency, total tau, neurofilament light chain, and cortical thickness measured by MRI. Our results add to increasing evidence that plasma Ptau 181 and 217 concentrations are valid Alzheimer's disease biomarkers in diverse populations.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationBrickman AM, Manly JJ, Honig LS, et al. Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease. Ann Clin Transl Neurol. 2022;9(5):756-761. doi:10.1002/acn3.51529en_US
dc.identifier.urihttps://hdl.handle.net/1805/33928
dc.language.isoen_USen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/acn3.51529en_US
dc.relation.journalAnnals of Clinical and Translational Neurologyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourcePMCen_US
dc.subjectAlzheimer diseaseen_US
dc.subjectBiomarkersen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectNeuroimagingen_US
dc.titleCorrelation of plasma and neuroimaging biomarkers in Alzheimer’s diseaseen_US
dc.typeArticleen_US
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