Effectiveness of implementing a wake up and breathe program on sedation and delirium in the ICU
dc.contributor.author | Khan, Babar A. | |
dc.contributor.author | Fadel, William F. | |
dc.contributor.author | Tricker, Jason L. | |
dc.contributor.author | Carlos, W. Graham | |
dc.contributor.author | Farber, Mark O. | |
dc.contributor.author | Hui, Siu L. | |
dc.contributor.author | Campbell, Noll L. | |
dc.contributor.author | Ely, E. Wesley | |
dc.contributor.author | Boustani, Malaz A. | |
dc.contributor.department | Department of Medicine, IU School of Medicine | en_US |
dc.date.accessioned | 2016-11-22T17:49:53Z | |
dc.date.available | 2016-11-22T17:49:53Z | |
dc.date.issued | 2014-12 | |
dc.description.abstract | OBJECTIVES: Mechanically ventilated critically ill patients receive significant amounts of sedatives and analgesics that increase their risk of developing coma and delirium. We evaluated the impact of a "Wake-up and Breathe Protocol" at our local ICU on sedation and delirium. DESIGN: A pre/post implementation study design. SETTING: A 22-bed mixed surgical and medical ICU. PATIENTS: Seven hundred two consecutive mechanically ventilated ICU patients from June 2010 to January 2013. INTERVENTIONS: Implementation of daily paired spontaneous awakening trials (daily sedation vacation plus spontaneous breathing trials) as a quality improvement project. MEASUREMENTS AND MAIN RESULTS: After implementation of our program, there was an increase in the mean Richmond Agitation Sedation Scale scores on weekdays of 0.88 (p < 0.0001) and an increase in the mean Richmond Agitation Sedation Scale scores on weekends of 1.21 (p < 0.0001). After adjusting for age, race, gender, severity of illness, primary diagnosis, and ICU, the incidence and prevalence of delirium did not change post implementation of the protocol (incidence: 23% pre vs 19.6% post; p = 0.40; prevalence: 66.7% pre vs 55.3% post; p = 0.06). The combined prevalence of delirium/coma decreased from 90.8% pre protocol implementation to 85% postimplementation (odds ratio, 0.505; 95% CI, 0.299-0.853; p = 0.01). CONCLUSIONS: Implementing a "Wake Up and Breathe Program" resulted in reduced sedation among critically ill mechanically ventilated patients but did not change the incidence or prevalence of delirium. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Khan, B. A., Fadel, W. F., Tricker, J. L., Carlos, W. G., Farber, M. O., Hui, S. L., … Boustani, M. A. (2014). Effectiveness of Implementing a Wake up and Breathe Program on Sedation and Delirium in the Intensive Care Unit. Critical Care Medicine, 42(12), e791–e795. http://doi.org/10.1097/CCM.0000000000000660 | en_US |
dc.identifier.issn | 1530-0293 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/11488 | |
dc.language.iso | en_US | en_US |
dc.publisher | Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins | en_US |
dc.relation.isversionof | 10.1097/CCM.0000000000000660 | en_US |
dc.relation.journal | Critical Care Medicine | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Critical Illness | en_US |
dc.subject | Deep Sedation | en_US |
dc.subject | methods | en_US |
dc.subject | Delirium | en_US |
dc.subject | prevention & control | en_US |
dc.subject | Respiration | en_US |
dc.subject | Respiration, Artificial | en_US |
dc.title | Effectiveness of implementing a wake up and breathe program on sedation and delirium in the ICU | en_US |
dc.type | Article | en_US |