MYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High-grade Serous Ovarian Cancer

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dc.contributor.authorWilliams, Imade
dc.contributor.authorO’Malley, Matthew
dc.contributor.authorDeHart, Haddie
dc.contributor.authorWalker, Bobby
dc.contributor.authorUlhaskumar, Vrushabh
dc.contributor.authorJothirajah, Pranav
dc.contributor.authorRay, Haimanti
dc.contributor.authorLandrum, Lisa M.
dc.contributor.authorDelaney, Joe R.
dc.contributor.authorNephew, Kenneth P.
dc.contributor.authorCarpenter, Richard L.
dc.contributor.departmentObstetrics and Gynecology, School of Medicine
dc.date.accessioned2025-03-24T13:29:36Z
dc.date.available2025-03-24T13:29:36Z
dc.date.issued2025
dc.description.abstractWe show that HSF1 and MYC genes are co-amplified in more than 30% of HGSOC and demonstrate that HSF1 and MYC functionally cooperate to drive the growth of HGSOC cells. This work provides the foundation for HSF1 and MYC co-amplification as a biomarker for treatment efficacy of the polo-like kinase 1 inhibitor volasertib in HGSOC.
dc.eprint.versionFinal published version
dc.identifier.citationWilliams I, O'Malley M, DeHart H, et al. MYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High-grade Serous Ovarian Cancer. Cancer Res Commun. 2025;5(2):253-266. doi:10.1158/2767-9764.CRC-24-0400
dc.identifier.urihttps://hdl.handle.net/1805/46512
dc.language.isoen_US
dc.publisherAmerican Association for Cancer Research
dc.relation.isversionof10.1158/2767-9764.CRC-24-0400
dc.relation.journalCancer Research Communications
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectCell cycle proteins
dc.subjectHeat shock transcription factors
dc.subjectProtein kinase inhibitors
dc.subjectProto-oncogene proteins
dc.subjectOvarian neoplasms
dc.titleMYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High-grade Serous Ovarian Cancer
dc.typeArticle
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