Assessing cortical bone porosity with MRI in an animal model of chronic kidney disease
dc.contributor.author | Newman, Christopher L. | |
dc.contributor.author | Surowiec, Rachel K. | |
dc.contributor.author | Swallow, Elizabeth A. | |
dc.contributor.author | Metzger, Corinne E. | |
dc.contributor.author | Kim, Jieun | |
dc.contributor.author | Tomaschke, Andrew A. | |
dc.contributor.author | Chen, Neal X. | |
dc.contributor.author | Allen, Matthew R. | |
dc.contributor.author | Wallace, Joseph M. | |
dc.contributor.author | Moe, Sharon M. | |
dc.contributor.author | Wu, Yu-Chien | |
dc.contributor.author | Niziolek, Paul J. | |
dc.contributor.department | Radiology and Imaging Sciences, School of Medicine | |
dc.date.accessioned | 2024-08-26T10:00:13Z | |
dc.date.available | 2024-08-26T10:00:13Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Chronic kidney disease (CKD) is characterized by secondary hyperparathyroidism and an increased risk of hip fractures predominantly related to cortical porosity. Unfortunately, bone mineral density measurements and high-resolution peripheral computed tomography (HR-pQCT) imaging have shortcomings that limit their utility in these patients. Ultrashort echo time magnetic resonance imaging (UTE-MRI) has the potential to overcome these limitations by providing an alternative assessment of cortical porosity. The goal of the current study was to determine if UTE-MRI could detect changes in porosity in an established rat model of CKD. Cy/+ rats (n = 11), an established animal model of CKD-MBD, and their normal littermates (n = 12) were imaged using microcomputed tomography (microCT) and UTE-MRI at 30 and 35 weeks of age (which approximates late-stage kidney disease in humans). Images were obtained at the distal tibia and the proximal femur. Cortical porosity was assessed using the percent porosity (Pore%) calculated from microCT imaging and the porosity index (PI) calculated from UTE-MRI. Correlations between Pore% and PI were also calculated. Cy/+ rats had higher Pore% than normal rats at both skeletal sites at 35 weeks (tibia = 7.13 % +/- 5.59 % vs. 0.51 % +/- 0.09 %, femur = 19.99 % +/- 7.72 % vs. 2.72 % +/- 0.32 %). They also had greater PI at the distal tibia at 30 weeks of age (0.47 +/- 0.06 vs. 0.40 +/- 0.08). However, Pore% and PI were only correlated in the proximal femur at 35 weeks of age (ρ = 0.929, Spearman). These microCT results are consistent with prior studies in this animal model utilizing microCT imaging. The UTE-MRI results were inconsistent, resulting in variable correlations with microCT imaging, which may be related to suboptimal bound and pore water discrimination at higher magnetic field strengths. Nevertheless, UTE-MRI may still provide an additional clinical tool to assess fracture risk without using ionizing radiation in CKD patients. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Newman CL, Surowiec RK, Swallow EA, et al. Assessing cortical bone porosity with MRI in an animal model of chronic kidney disease. Bone. 2023;173:116808. doi:10.1016/j.bone.2023.116808 | |
dc.identifier.uri | https://hdl.handle.net/1805/42925 | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | |
dc.relation.isversionof | 10.1016/j.bone.2023.116808 | |
dc.relation.journal | Bone | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Chronic kidney disease | |
dc.subject | MRI | |
dc.subject | Porosity index | |
dc.subject | Ultrashort echo time magnetic resonance imaging (UTE-MRI) | |
dc.title | Assessing cortical bone porosity with MRI in an animal model of chronic kidney disease | |
dc.type | Article |