Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014
dc.contributor.author | Weiner, Michael W. | |
dc.contributor.author | Veitch, Dallas P. | |
dc.contributor.author | Aisen, Paul S. | |
dc.contributor.author | Beckett, Laurel A. | |
dc.contributor.author | Cairns, Nigel J. | |
dc.contributor.author | Cedarbaum, Jesse | |
dc.contributor.author | Donohue, Michael C. | |
dc.contributor.author | Green, Robert C. | |
dc.contributor.author | Harvey, Danielle | |
dc.contributor.author | Jack, Clifford R. | |
dc.contributor.author | Jagust, William | |
dc.contributor.author | Morris, John C. | |
dc.contributor.author | Petersen, Ronald C. | |
dc.contributor.author | Saykin, Andrew J. | |
dc.contributor.author | Shaw, Leslie | |
dc.contributor.author | Thompson, Paul M. | |
dc.contributor.author | Toga, Arthur W. | |
dc.contributor.author | Trojanowski, John Q. | |
dc.contributor.author | Alzheimer's Disease Neuroimaging Initiative | |
dc.contributor.department | Department of Radiology and Imaging Sciences, IU School of Medicine | en_US |
dc.date.accessioned | 2017-06-19T17:38:36Z | |
dc.date.available | 2017-06-19T17:38:36Z | |
dc.date.issued | 2015-07 | |
dc.description.abstract | INTRODUCTION: The Alzheimer's Disease Neuroimaging Initiative (ADNI) was established in 2004 to facilitate the development of effective treatments for Alzheimer's disease (AD) by validating biomarkers for AD clinical trials. METHODS: We searched for ADNI publications using established methods. RESULTS: ADNI has (1) developed standardized biomarkers for use in clinical trial subject selection and as surrogate outcome measures; (2) standardized protocols for use across multiple centers; (3) initiated worldwide ADNI; (4) inspired initiatives investigating traumatic brain injury and post-traumatic stress disorder in military populations, and depression, respectively, as an AD risk factor; (5) acted as a data-sharing model; (6) generated data used in over 600 publications, leading to the identification of novel AD risk alleles, and an understanding of the relationship between biomarkers and AD progression; and (7) inspired other public-private partnerships developing biomarkers for Parkinson's disease and multiple sclerosis. DISCUSSION: ADNI has made myriad impacts in its first decade. A competitive renewal of the project in 2015 would see the use of newly developed tau imaging ligands, and the continued development of recruitment strategies and outcome measures for clinical trials. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Weiner, M. W., Veitch, D. P., Aisen, P. S., Beckett, L. A., Cairns, N. J., Cedarbaum, J., … Alzheimer’s Disease Neuroimaging Initiative. (2015). Impact of the Alzheimer’s Disease Neuroimaging Initiative, 2004 to 2014. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 11(7), 865–884. http://doi.org/10.1016/j.jalz.2015.04.005 | en_US |
dc.identifier.issn | 1552-5279 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/13089 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.jalz.2015.04.005 | en_US |
dc.relation.journal | Alzheimer's & Dementia: The Journal of the Alzheimer's Association | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Alzheimer Disease | en_US |
dc.subject | diagnosis | en_US |
dc.subject | therapy | en_US |
dc.subject | Neuroimaging | en_US |
dc.subject | methods | en_US |
dc.subject | Clinical Trials as Topic | en_US |
dc.subject | Databases, Bibliographic | en_US |
dc.subject | statistics & numerical data | en_US |
dc.title | Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014 | en_US |
dc.type | Article | en_US |
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