Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

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dc.contributor.authorWalters, Raymond K.
dc.contributor.authorPolimanti, Renato
dc.contributor.authorJohnson, Emma C.
dc.contributor.authorMcClintick, Jeanette N.
dc.contributor.authorAdams, Mark J.
dc.contributor.authorAdkins, Amy E.
dc.contributor.authorAliev, Fazil
dc.contributor.authorBacanu, Silviu-Alin
dc.contributor.authorBatzler, Anthony
dc.contributor.authorBertelsen, Sarah
dc.contributor.authorBiernacka, Joanna M.
dc.contributor.authorBigdeli, Tim B.
dc.contributor.authorChen, Li-Shiun
dc.contributor.authorClarke, Toni-Kim
dc.contributor.authorChou, Yi-Ling
dc.contributor.authorDegenhardt, Franziska
dc.contributor.authorDocherty, Anna R.
dc.contributor.authorEdwards, Alexis C.
dc.contributor.authorFontanillas, Pierre
dc.contributor.authorFoo, Jerome C.
dc.contributor.authorFox, Louis
dc.contributor.authorFrank, Josef
dc.contributor.authorGiegling, Ina
dc.contributor.authorGordon, Scott
dc.contributor.authorHack, Laura M.
dc.contributor.authorHartmann, Annette M.
dc.contributor.authorHartz, Sarah M.
dc.contributor.authorHeilmann-Heimbach, Stefanie
dc.contributor.authorHerms, Stefan
dc.contributor.authorHodgkinson, Colin
dc.contributor.authorHoffmann, Per
dc.contributor.authorHottenga, Jouke Jan
dc.contributor.authorKennedy, Martin A.
dc.contributor.authorAlanne-Kinnunen, Mervi
dc.contributor.authorKonte, Bettina
dc.contributor.authorLahti, Jari
dc.contributor.authorLahti-Pulkkinen, Marius
dc.contributor.authorLai, Dongbing
dc.contributor.authorLigthart, Lannie
dc.contributor.authorLoukola, Anu
dc.contributor.authorMaher, Brion S.
dc.contributor.authorMbarek, Hamdi
dc.contributor.authorMcIntosh, Andrew M.
dc.contributor.authorMcQueen, Matthew B.
dc.contributor.authorMeyers, Jacquelyn L.
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorPalviainen, Teemu
dc.contributor.authorPearson, John F.
dc.contributor.authorPeterson, Roseann E.
dc.contributor.authorRipatti, Samuli
dc.contributor.authorRyu, Euijung
dc.contributor.authorSaccone, Nancy L.
dc.contributor.authorSalvatore, Jessica E.
dc.contributor.authorSanchez-Roige, Sandra
dc.contributor.authorSchwandt, Melanie
dc.contributor.authorSherva, Richard
dc.contributor.authorStreit, Fabian
dc.contributor.authorStrohmaier, Jana
dc.contributor.authorThomas, Nathaniel
dc.contributor.authorWang, Jen-Chyong
dc.contributor.authorWebb, Bradley T.
dc.contributor.authorWedow, Robbee
dc.contributor.authorWetherill, Leah
dc.contributor.authorWills, Amanda G.
dc.contributor.authorBoardman, Jason D.
dc.contributor.authorChen, Danfeng
dc.contributor.authorChoi, Doo-Sup
dc.contributor.authorCopeland, William E.
dc.contributor.authorCulverhouse, Robert C.
dc.contributor.authorDahmen, Norbert
dc.contributor.authorDegenhardt, Louisa
dc.contributor.authorDomingue, Benjamin W.
dc.contributor.authorElson, Sarah L.
dc.contributor.authorFrye, Mark A.
dc.contributor.authorGäbel, Wolfgang
dc.contributor.authorHayward, Caroline
dc.contributor.authorIsing, Marcus
dc.contributor.authorKeyes, Margaret
dc.contributor.authorKiefer, Falk
dc.contributor.authorKramer, John
dc.contributor.authorKuperman, Samuel
dc.contributor.authorLucae, Susanne
dc.contributor.authorLynskey, Michael T.
dc.contributor.authorMaier, Wolfgang
dc.contributor.authorMann, Karl
dc.contributor.authorMännistö, Satu
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorMurray, Alison D.
dc.contributor.authorNurnberger, John I.
dc.contributor.authorPalotie, Aarno
dc.contributor.authorPreuss, Ulrich
dc.contributor.authorRäikkönen, Katri
dc.contributor.authorReynolds, Maureen D.
dc.contributor.authorRidinger, Monika
dc.contributor.authorScherbaum, Norbert
dc.contributor.authorSchuckit, Marc A.
dc.contributor.authorSoyka, Michael
dc.contributor.authorTreutlein, Jens
dc.contributor.authorWitt, Stephanie
dc.contributor.authorWodarz, Norbert
dc.contributor.authorZill, Peter
dc.contributor.authorAdkins, Daniel E.
dc.contributor.authorBoden, Joseph M.
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorBierut, Laura J.
dc.contributor.authorBrown, Sandra A.
dc.contributor.authorBucholz, Kathleen K.
dc.contributor.authorCichon, Sven
dc.contributor.authorCostello, E. Jane
dc.contributor.authorde Wit, Harriet
dc.contributor.authorDiazgranados, Nancy
dc.contributor.authorDick, Danielle M.
dc.contributor.authorEriksson, Johan G.
dc.contributor.authorFarrer, Lindsay A.
dc.contributor.authorForoud, Tatiana M.
dc.contributor.authorGillespie, Nathan A.
dc.contributor.authorGoate, Alison M.
dc.contributor.authorGoldman, David
dc.contributor.authorGrucza, Richard A.
dc.contributor.authorHancock, Dana B.
dc.contributor.authorHarris, Kathleen Mullan
dc.contributor.authorHeath, Andrew C.
dc.contributor.authorHesselbrock, Victor
dc.contributor.authorHewitt, John K.
dc.contributor.authorHopfer, Christian J.
dc.contributor.authorHorwood, John
dc.contributor.authorIacono, William
dc.contributor.authorJohnson, Eric O.
dc.contributor.authorKaprio, Jaakko A.
dc.contributor.authorKarpyak, Victor M.
dc.contributor.authorKendler, Kenneth S.
dc.contributor.authorKranzler, Henry R.
dc.contributor.authorKrauter, Kenneth
dc.contributor.authorLichtenstein, Paul
dc.contributor.authorLind, Penelope A.
dc.contributor.authorMcGue, Matt
dc.contributor.authorMacKillop, James
dc.contributor.authorMadden, Pamela A. F.
dc.contributor.authorMaes, Hermine H.
dc.contributor.authorMagnusson, Patrik
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMedland, Sarah E.
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorNelson, Elliot C.
dc.contributor.authorNöthen, Markus M.
dc.contributor.authorPalmer, Abraham A.
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorPenninx, Brenda W.J.H.
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorRice, John P.
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRiley, Brien P.
dc.contributor.authorRose, Richard
dc.contributor.authorRujescu, Dan
dc.contributor.authorShen, Pei-Hong
dc.contributor.authorSilberg, Judy
dc.contributor.authorStallings, Michael C.
dc.contributor.authorTarter, Ralph E.
dc.contributor.authorVanyukov, Michael M.
dc.contributor.authorVrieze, Scott
dc.contributor.authorWall, Tamara L.
dc.contributor.authorWhitfield, John B.
dc.contributor.authorZhao, Hongyu
dc.contributor.authorNeale, Benjamin M.
dc.contributor.authorGelernter, Joel
dc.contributor.authorEdenberg, Howard J.
dc.contributor.authorAgrawal, Arpana
dc.contributor.departmentBiochemistry and Molecular Biology, School of Medicineen_US
dc.date.accessioned2019-08-14T14:55:19Z
dc.date.available2019-08-14T14:55:19Z
dc.date.issued2018-12
dc.description.abstractLiability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 × 10-13) and African ancestries (rs2066702; P = 2.2 × 10-9). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, attention deficit-hyperactivity disorder, depression, and use of cigarettes and cannabis. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationWalters, R. K., Polimanti, R., Johnson, E. C., McClintick, J. N., Adams, M. J., Adkins, A. E., … Agrawal, A. (2018). Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nature neuroscience, 21(12), 1656–1669. doi:10.1038/s41593-018-0275-1en_US
dc.identifier.urihttps://hdl.handle.net/1805/20358
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isversionof10.1038/s41593-018-0275-1en_US
dc.relation.journalNature Neuroscienceen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectGenome-wide association studyen_US
dc.subjectAlcoholismen_US
dc.subjectPsychiatric disordersen_US
dc.subjectAlcohol useen_US
dc.subjectPleiotropyen_US
dc.titleTransancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disordersen_US
dc.typeArticleen_US
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