Hypoxia signaling: Challenges and opportunities for cancer therapy
| dc.contributor.author | Ivan, Mircea | |
| dc.contributor.author | Fishel, Melissa L. | |
| dc.contributor.author | Tudoran, Oana M. | |
| dc.contributor.author | Pollok, Karen E. | |
| dc.contributor.author | Wu, Xue | |
| dc.contributor.author | Smith, Paul J. | |
| dc.contributor.department | Microbiology and Immunology, School of Medicine | |
| dc.date.accessioned | 2024-06-10T17:34:25Z | |
| dc.date.available | 2024-06-10T17:34:25Z | |
| dc.date.issued | 2022-10 | |
| dc.description.abstract | Hypoxia is arguably the first recognized cancer microenvironment hallmark and affects virtually all cellular populations present in tumors. During the past decades the complex adaptive cellular responses to oxygen deprivation have been largely elucidated, raising hope for new anti cancer agents. Despite undeniable preclinical progress, therapeutic targeting of tumor hypoxia is yet to transition from bench to bedside. This review focuses on new pharmacological agents that exploit tumor hypoxia or interfere with hypoxia signaling and discusses strategies to maximize their therapeutic impact. | |
| dc.eprint.version | Author's manuscript | |
| dc.identifier.citation | Ivan, M., Fishel, M. L., Tudoran, O. M., Pollok, K. E., Wu, X., & Smith, P. J. (2022). Hypoxia signaling: Challenges and opportunities for cancer therapy. Seminars in Cancer Biology, 85, 185–195. https://doi.org/10.1016/j.semcancer.2021.10.002 | |
| dc.identifier.uri | https://hdl.handle.net/1805/41349 | |
| dc.language.iso | en_US | |
| dc.publisher | Elsevier | |
| dc.relation.isversionof | 10.1016/j.semcancer.2021.10.002 | |
| dc.relation.journal | Seminars in Cancer Biology | |
| dc.rights | Publisher Policy | |
| dc.source | PMC | |
| dc.subject | Hypoxia | |
| dc.subject | HIF1 | |
| dc.subject | HIF2 | |
| dc.subject | HIF inhibitors | |
| dc.subject | Hypoxia-activated prodrug | |
| dc.title | Hypoxia signaling: Challenges and opportunities for cancer therapy | |
| dc.type | Article |