Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence

dc.contributor.authorBarr, Peter B.
dc.contributor.authorNeale, Zoe
dc.contributor.authorSchulman, Jessica
dc.contributor.authorMullins, Niamh
dc.contributor.authorZhang, Jian
dc.contributor.authorChorlian, David B.
dc.contributor.authorKamarajan, Chella
dc.contributor.authorKinreich, Sivan
dc.contributor.authorPandey, Ashwini K.
dc.contributor.authorPandey, Gayathri
dc.contributor.authorSaenz de Viteri, Stacey
dc.contributor.authorAcion, Laura
dc.contributor.authorBauer, Lance
dc.contributor.authorBucholz, Kathleen K.
dc.contributor.authorChan, Grace
dc.contributor.authorChao, Michael
dc.contributor.authorDick, Danielle M.
dc.contributor.authorEdenberg, Howard J.
dc.contributor.authorForoud, Tatiana
dc.contributor.authorGoate, Alison
dc.contributor.authorHesselbrock, Victor
dc.contributor.authorJohnson, Emma C.
dc.contributor.authorKramer, John
dc.contributor.authorLai, Dongbing
dc.contributor.authorPlawecki, Martin H.
dc.contributor.authorSalvatore, Jessica E.
dc.contributor.authorWetherill, Leah
dc.contributor.authorAgrawal, Arpana
dc.contributor.authorPorjesz, Bernice
dc.contributor.authorMeyers, Jacquelyn L.
dc.contributor.departmentMedical and Molecular Genetics, School of Medicine
dc.date.accessioned2024-01-10T17:50:09Z
dc.date.available2024-01-10T17:50:09Z
dc.date.issued2023-04-29
dc.description.abstractResearch has identified clinical, genomic, and neurophysiological markers associated with suicide attempts (SA) among individuals with psychiatric illness. However, there is limited research among those with an alcohol use disorder, despite their disproportionately higher rates of SA. We examined lifetime SA in 4,068 individuals with DSM-IV alcohol dependence from the Collaborative Study on the Genetics of Alcoholism (23% lifetime suicide attempt; 53% female; 17% Admixed African American ancestries; mean age: 38). We 1) explored clinical risk factors associated with SA, 2) conducted a genome-wide association study of SA, 3) examined whether individuals with a SA had elevated polygenic scores for comorbid psychiatric conditions (e.g., alcohol use disorders, lifetime suicide attempt, and depression), and 4) explored differences in electroencephalogram neural functional connectivity between those with and without a SA. One gene-based finding emerged, RFX3 (Regulatory Factor X, located on 9p24.2) which had supporting evidence in prior research of SA among individuals with major depression. Only the polygenic score for suicide attempts was associated with reporting a suicide attempt (OR = 1.20, 95% CI = 1.06, 1.37). Lastly, we observed decreased right hemispheric frontal-parietal theta and decreased interhemispheric temporal-parietal alpha electroencephalogram resting-state coherences among those participants who reported a SA relative to those who did not, but differences were small. Overall, individuals with alcohol dependence who report SA appear to experience a variety of severe comorbidities and elevated polygenic risk for SA. Our results demonstrate the need to further investigate suicide attempts in the presence of substance use disorders.
dc.eprint.versionPre-Print
dc.identifier.citationBarr PB, Neale Z, Schulman J, et al. Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence. Preprint. medRxiv. 2023;2023.04.28.23289173. Published 2023 Apr 29. doi:10.1101/2023.04.28.23289173
dc.identifier.urihttps://hdl.handle.net/1805/37949
dc.language.isoen_US
dc.publishermedRxiv
dc.relation.isversionof10.1101/2023.04.28.23289173
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcePMC
dc.subjectSuicide attempts (SA)
dc.subjectPsychiatric illness
dc.subjectAlcohol use disorder
dc.subjectComorbidities
dc.subjectPolygenic risk
dc.titleClinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence
dc.typeArticle
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