Exercise activates compensatory thermoregulatory reaction in rats: a modeling study

dc.contributor.authorYoo, Yeonjoo
dc.contributor.authorLaPradd, Michelle
dc.contributor.authorKline, Hannah
dc.contributor.authorZaretskaia, Maria V.
dc.contributor.authorBehrouzvaziri, Abolhassan
dc.contributor.authorRusyniak, Daniel E.
dc.contributor.authorMolkov, Yaroslav I.
dc.contributor.authorZaretsky, Dmitry V.
dc.contributor.departmentDepartment of Mathematical Sciences, School of Scienceen_US
dc.date.accessioned2017-06-14T20:05:41Z
dc.date.available2017-06-14T20:05:41Z
dc.date.issued2015-12-15
dc.description.abstractThe importance of exercise is increasingly emphasized for maintaining health. However, exercise itself can pose threats to health such as the development of exertional heat shock in warm environments. Therefore, it is important to understand how the thermoregulation system adjusts during exercise and how alterations of this can contribute to heat stroke. To explore this we measured the core body temperature of rats (Tc) running for 15 min on a treadmill at various speeds in two ambient temperatures (Ta = 25°C and 32°C). We assimilated the experimental data into a mathematical model that describes temperature changes in two compartments of the body, representing the muscles and the core. In our model the core body generates heat to maintain normal body temperature, and dissipates it into the environment. The muscles produce additional heat during exercise. According to the estimation of model parameters, at Ta = 25°C, the heat generation in the core was progressively reduced with the increase of the treadmill speed to compensate for a progressive increase in heat production by the muscles. This compensation was ineffective at Ta = 32°C, which resulted in an increased rate of heat accumulation with increasing speed, as opposed to the Ta = 25°C case. Interestingly, placing an animal on a treadmill increased heat production in the muscles even when the treadmill speed was zero. Quantitatively, this "ready-to-run" phenomenon accounted for over half of the heat generation in the muscles observed at maximal treadmill speed. We speculate that this anticipatory response utilizes stress-related circuitry.en_US
dc.identifier.citationYoo, Y., LaPradd, M., Kline, H., Zaretskaia, M. V., Behrouzvaziri, A., Rusyniak, D. E., … Zaretsky, D. V. (2015). Exercise activates compensatory thermoregulatory reaction in rats: a modeling study. Journal of Applied Physiology, 119(12), 1400–1410. http://doi.org/10.1152/japplphysiol.00392.2015en_US
dc.identifier.urihttps://hdl.handle.net/1805/13047
dc.language.isoen_USen_US
dc.publisherAmerican Psychological Societyen_US
dc.relation.isversionof10.1152/japplphysiol.00392.2015en_US
dc.relation.journalJournal of Applied Physiologyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectExerciseen_US
dc.subjectTreadmillen_US
dc.subjectBody temperatureen_US
dc.subjectThermoregulationen_US
dc.titleExercise activates compensatory thermoregulatory reaction in rats: a modeling studyen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683350/en_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Exercise activates compensatory thermoregulatory reaction in rats_ a modeling st.pdf
Size:
721.61 KB
Format:
Adobe Portable Document Format
Description:
Main Article
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.88 KB
Format:
Item-specific license agreed upon to submission
Description: