Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase (HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii

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dc.contributor.authorSmith, Aaron T.
dc.contributor.authorLivingston, Meredith R.
dc.contributor.authorMai, Antonello
dc.contributor.authorFiletici, Patrizia
dc.contributor.authorQueener, Sherry F.
dc.contributor.authorSullivan, William J., Jr.
dc.contributor.departmentPharmacology and Toxicology, School of Medicine
dc.date.accessioned2024-08-29T15:13:37Z
dc.date.available2024-08-29T15:13:37Z
dc.date.issued2007
dc.description.abstractWe report that quinoline derivative MC1626, first described as an inhibitor of the histone acetyltransferase (HAT) GCN5, is active against the protozoan parasite Toxoplasma gondii in vitro. However, MC1626 does not inhibit Toxoplasma GCN5 HATs or reduce HAT-mediated activity; rather, this quinoline may target the plastid organelle called the apicoplast.
dc.eprint.versionFinal published version
dc.identifier.citationSmith AT, Livingston MR, Mai A, Filetici P, Queener SF, Sullivan WJ Jr. Quinoline derivative MC1626, a putative GCN5 histone acetyltransferase (HAT) inhibitor, exhibits HAT-independent activity against Toxoplasma gondii. Antimicrob Agents Chemother. 2007;51(3):1109-1111. doi:10.1128/AAC.01256-06
dc.identifier.urihttps://hdl.handle.net/1805/43036
dc.language.isoen_US
dc.publisherAmerican Society for Microbiology
dc.relation.isversionof10.1128/AAC.01256-06
dc.relation.journalAntimicrobial Agents and Chemotherapy
dc.rightsPublisher Policy
dc.sourcePMC
dc.subjectAntiprotozoal agents
dc.subjectEnzyme inhibitors
dc.subjectHistone acetyltransferases
dc.subjectOrganelles
dc.subjectQuinolines
dc.subjectSaccharomyces cerevisiae
dc.subjectToxoplasma
dc.titleQuinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase (HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii
dc.typeArticle
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803115/
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