Adherence to Surveillance Guidelines in Nondysplastic Barrett’s Esophagus
dc.contributor.author | Dalal, Kunal S. | |
dc.contributor.author | Coffing, Jessica | |
dc.contributor.author | Imperiale, Thomas F. | |
dc.contributor.department | Department of Medicine, School of Medicine | en_US |
dc.date.accessioned | 2017-10-05T16:59:30Z | |
dc.date.available | 2017-10-05T16:59:30Z | |
dc.date.issued | 2016 | |
dc.description.abstract | Introduction: Surveillance patterns in Barrett's esophagus (BE) are not well characterized. Guidelines published between 2002 and 2008 recommended surveillance esophagogastroduodenoscopy (sEGD) at 3-year intervals for nondysplastic BE (NDBE). We assessed guideline adherence in incident NDBE in a Veterans Affairs (VA)-based study. Methods: At a single VA center, we identified incident cases of biopsy-confirmed NDBE between January, 2006 and December, 2008. We excluded patients aged 76 years and above and those who developed BE-associated dysplasia or cancer during follow-up. All sEGDs through October, 2014 were documented. Our primary criteria classified cases as guideline adherent if a sEGD was performed within 6 months of each expected 3-year surveillance interval; in cases with >=2 sEGDs, 1 sEGD >6 months, and <=1 year outside an interval was allowed if the average interval was between 2.5 and 3.5 years. Comorbidity, primary care encounters, presence of long-segment BE (LSBE), endoscopist recommendations, and Charlson comorbidity index (CCI) were assessed. Results: We identified 110 patients (96.4% male, 93.6% white) with mean age 58.9+/-8.5 years at index EGD. Median follow-up was 6.7 years (range, 3.7 to 8.6). Thirty-three (30.0%) cases were guideline adherent; 77 (70.0%) cases were nonadherent, including 52 (47.3%) with irregular surveillance and 25 (22.7%) with no surveillance. Forty cases (14 adherent) had 1 sEGD, 36 (18 adherent) had 2, 8 (1 adherent) had 3, and 1 nonadherent case had 4. Adherent cases were significantly older (61.5 vs. 57.9 y, P=0.04), and tended to have more LSBE (33.3% vs. 20.8%, P=0.16). There were no differences between adherent and nonadherent cases in annual primary care encounters (72.7% vs. 66.2%, P=0.66), CCI>=4 (15.2% vs. 15.6%, P=0.95), biopsy-positive sEGDs (75.8% vs. 76.6%, P=0.92), and any recommendation for subsequent surveillance (81.8% vs. 77.9%, P=0.65). A logistic regression model using age, CCI, and LSBE showed an independent association between adherence and older age (P=0.03). Conclusions: In a single-center VA cohort, sEGD of NDBE was mostly nonadherent to guidelines. Adherent cases were older at baseline with a trend toward more LSBE. A larger study is needed to identify medical and social factors associated with adherence or nonadherence to surveillance. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Dalal, K. S., Coffing, J., & Imperiale, T. F. (2016). Adherence to Surveillance Guidelines in Nondysplastic Barrett’s Esophagus. Journal of Clinical Gastroenterology, https://doi.org/10.1097/MCG.0000000000000777 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/14242 | |
dc.language.iso | en | en_US |
dc.publisher | Wolters Kluwer | en_US |
dc.relation.isversionof | 10.1097/MCG.0000000000000777 | en_US |
dc.relation.journal | Journal of Clinical Gastroenterology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | Author | en_US |
dc.subject | surveillance patterns | en_US |
dc.subject | Barrett's esophagus | en_US |
dc.subject | guidelines | en_US |
dc.title | Adherence to Surveillance Guidelines in Nondysplastic Barrett’s Esophagus | en_US |
dc.type | Article | en_US |