Ventral frontal satiation-mediated responses to food aromas in obese and normal-weight women

dc.contributor.authorEiler II, William J.A.
dc.contributor.authorDzemidzic, Mario
dc.contributor.authorCase, K. Rose
dc.contributor.authorArmstrong, Cheryl L.H.
dc.contributor.authorMattes, Richard D.
dc.contributor.authorCyders, Melissa A.
dc.contributor.authorConsidine, Robert V.
dc.contributor.authorKareken, David A.
dc.contributor.departmentDepartment of Psychiatry, IU School of Medicineen_US
dc.date.accessioned2016-06-27T13:53:11Z
dc.date.available2016-06-27T13:53:11Z
dc.date.issued2014-06-02
dc.description.abstractBACKGROUND: Sensory properties of foods promote and guide consumption in hunger states, whereas satiation should dampen the sensory activation of ingestive behaviors. Such activation may be disordered in obese individuals. OBJECTIVE: Using functional magnetic resonance imaging (fMRI), we studied regional brain responses to food odor stimulation in the sated state in obese and normal-weight individuals targeting ventral frontal regions known to be involved in coding for stimulus reward value. DESIGN: Forty-eight women (25 normal weight; 23 obese) participated in a 2-day (fed compared with fasting) fMRI study while smelling odors of 2 foods and an inedible, nonfood object. Analyses were conducted to permit an examination of both general and sensory-specific satiation (satiation effects specific to a given food). RESULTS: Normal-weight subjects showed significant blood oxygen level-dependent responses in the ventromedial prefrontal cortex (vmPFC) to food aromas compared with responses induced by the odor of an inedible object. Normal-weight subjects also showed general (but not sensory-specific) satiation effects in both the vmPFC and orbitofrontal cortex. Obese subjects showed no differential response to the aromas of food and the inedible object when fasting. Within- and between-group differences in satiation were driven largely by changes in the response to the odor of the inedible stimulus. Responses to food aromas in the obese correlated with trait negative urgency, the tendency toward negative affect-provoked impulsivity. CONCLUSIONS: Ventral frontal signaling of reward value may be disordered in obesity, with negative urgency heightening responses to food aromas. The observed nature of responses to food and nonfood stimuli suggests that future research should independently quantify each to fully understand brain reward signaling in obesity.en_US
dc.identifier.citationEiler, W. J., Dzemidzic, M., Case, K. R., Armstrong, C. L., Mattes, R. D., Cyders, M. A., … Kareken, D. A. (2014). Ventral frontal satiation-mediated responses to food aromas in obese and normal-weight women. The American Journal of Clinical Nutrition, 99(6), 1309–1318. http://doi.org/10.3945/ajcn.113.080788en_US
dc.identifier.urihttps://hdl.handle.net/1805/10185
dc.publisherAmerican Society for Nutritionen_US
dc.relation.isversionof10.3945/ajcn.113.080788en_US
dc.relation.journalThe American Journal of Clinical Nutritionen_US
dc.sourcePMCen_US
dc.subjectBody Mass Indexen_US
dc.subjectBreakfasten_US
dc.subjectFastingen_US
dc.subjectFeeding behavioren_US
dc.subjectFemaleen_US
dc.subjectImaging, three-dimensionalen_US
dc.subjectImpulsive behavioren_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectObesity -- Metabolismen_US
dc.subjectPersonality testsen_US
dc.subjectPostprandial perioden_US
dc.subjectPrefrontal cortex -- Metabolismen_US
dc.subjectSatiety responseen_US
dc.subjectSensory receptor cells -- Metabolismen_US
dc.titleVentral frontal satiation-mediated responses to food aromas in obese and normal-weight womenen_US
dc.typeArticleen_US
ul.alternative.fulltexthttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021781/en_US
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