A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin*.

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dc.contributor.authorSimon, Jeremy M.
dc.contributor.authorParker, Joel S.
dc.contributor.authorLiu, Feng
dc.contributor.authorRothbart, Scott B.
dc.contributor.authorAit-Si-Ali, Slimane
dc.contributor.authorStrahl, Brian D.
dc.contributor.authorJin, Jian
dc.contributor.authorDavis, Ian J.
dc.contributor.authorMosley, Amber L.
dc.contributor.authorPattenden, Samantha G.
dc.contributor.departmentDepartment of Biochemistry and Molecular Biology, IU School of Medicineen_US
dc.date.accessioned2016-12-15T22:29:49Z
dc.date.available2016-12-15T22:29:49Z
dc.date.issued2015-10-23
dc.description.abstractBackground: G9a-GLP lysine methyltransferases mono- and di-methylate histone H3 lysine 9 (H3K9me2).Results: Widely interspaced zinc finger (WIZ) regulates H3K9me2 levels through a mechanism that involves retention of G9a on chromatin.Conclusion: The G9a-GLP-WIZ complex has unique functions when bound to chromatin that are independent of the H3K9me2 mark.Significance: Combining pharmacologic and genetic manipulations is essential to any translational hypotheses related to G9a function.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationSimon, J. M., Parker, J. S., Liu, F., Rothbart, S. B., Ait-Si-Ali, S., Strahl, B. D., … Pattenden, S. G. (2015). A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin. The Journal of Biological Chemistry, 290(43), 26088–26102. http://doi.org/10.1074/jbc.M115.654459en_US
dc.identifier.issn0021-9258 1083-351Xen_US
dc.identifier.urihttps://hdl.handle.net/1805/11624
dc.language.isoen_USen_US
dc.publisherASBMBen_US
dc.relation.isversionof10.1074/jbc.M115.654459en_US
dc.relation.journalThe Journal of Biological Chemistryen_US
dc.rightsPublisher's Policyen_US
dc.sourcePublisheren_US
dc.subjectchromatin modificationen_US
dc.subjectchromatin regulationen_US
dc.subjectprotein methylationen_US
dc.subjecttranscriptionen_US
dc.subjecttranscription coregulatoren_US
dc.titleA Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin*.en_US
dc.typeArticleen_US
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