Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma

dc.contributor.authorTimani, Khalid Amine
dc.contributor.authorGyőrffy, Balázs
dc.contributor.authorLiu, Ying
dc.contributor.authorMohammad, Khalid S.
dc.contributor.authorHe, Johnny J.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2019-05-09T18:25:51Z
dc.date.available2019-05-09T18:25:51Z
dc.date.issued2018-08-17
dc.description.abstractTip110, an important regulator of several oncogenic proteins, was significantly downregulated in human metastatic melanoma cells exposed to a hypoxic condition. Therefore, in this study, we set to determine whether differential expression of Tip110 could be an important indicator for melanoma tumorigenesis and metastasis. We found that in melanoma, but not in other cancer types, Tip110 knockdown enhanced significant expression and secretion of IL-8 and melanoma cells invasions. This induction was further potentiated under hypoxia and by inflammatory cytokine and found independent of TNF-α autocrine signaling. We further showed that Tip110 knockdown-mediated IL-8 induction involved IL-8 mRNA stability. Furthermore, the transcriptomic profiling data and survival from 455 melanoma patients demonstrated that the correlation between Tip110 expression and the clinical outcomes in melanoma was stage-dependent. These findings uncover important roles of Tip110 in melanoma tumorigenesis and metastasis through regulation of IL-8 and hope to provide new clues for future therapeutic strategies.en_US
dc.identifier.citationTimani, K. A., Győrffy, B., Liu, Y., Mohammad, K. S., & He, J. J. (2018). Tip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanoma. Molecular cancer, 17(1), 124. doi:10.1186/s12943-018-0868-zen_US
dc.identifier.urihttps://hdl.handle.net/1805/19202
dc.language.isoen_USen_US
dc.publisherBiomed Centralen_US
dc.relation.isversionof10.1186/s12943-018-0868-zen_US
dc.relation.journalMolecular Canceren_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/us*
dc.sourcePMCen_US
dc.subjectTip110/SART3en_US
dc.subjectIL-8en_US
dc.subjectMelanomaen_US
dc.subjectHypoxiaen_US
dc.subjectTP53en_US
dc.subjectNF-κBen_US
dc.titleTip110/SART3 regulates IL-8 expression and predicts the clinical outcomes in melanomaen_US
dc.typeArticleen_US
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