Clinical Management Update of Oral Leukoplakia: A Review From the American Head and Neck Society Cancer Prevention Service

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dc.contributor.authorGates, James C.
dc.contributor.authorAbouyared, Marianne
dc.contributor.authorShnayder, Yelizaveta
dc.contributor.authorFarwell, D. Gregory
dc.contributor.authorDay, Andrew
dc.contributor.authorAlawi, Faizan
dc.contributor.authorMoore, Michael
dc.contributor.authorHolcomb, Andrew J.
dc.contributor.authorBirkeland, Andrew
dc.contributor.authorEpstein, Joel
dc.contributor.departmentOtolaryngology -- Head and Neck Surgery, School of Medicine
dc.date.accessioned2025-02-26T13:00:43Z
dc.date.available2025-02-26T13:00:43Z
dc.date.issued2025
dc.description.abstractBackground: Oral potentially malignant disorders (OPMDs) occur in up to 4%-5% of the population, of which oral leukoplakia (OL) is the most common subtype. Predicting high-risk OL remains a challenge. Early diagnosis and effective treatment are thought to be of paramount importance to improve outcomes. Methods: We searched PubMed and Clinicaltrials.gov data for updates in the clinical management of OL from 2015 to current. Results: Recent publication of large cohorts of patients with OL aids in counseling patients regarding risk of malignant transformation. Management for OL includes surveillance, excision, and laser surgery, as well as local and systemic approaches to chemoprevention. Several new entities show promise regarding candidate biomarkers, chemoprevention agents, and diagnostic adjuncts, though all require further validation. Conclusion: This update serves to further inform clinical management of OL and provide impetus for future investigations.
dc.eprint.versionFinal published version
dc.identifier.citationGates JC, Abouyared M, Shnayder Y, et al. Clinical Management Update of Oral Leukoplakia: A Review From the American Head and Neck Society Cancer Prevention Service. Head Neck. 2025;47(2):733-741. doi:10.1002/hed.28013
dc.identifier.urihttps://hdl.handle.net/1805/46063
dc.language.isoen_US
dc.publisherWiley
dc.relation.isversionof10.1002/hed.28013
dc.relation.journalHead & Neck
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.sourcePMC
dc.subjectDysplasia
dc.subjectOral cancer
dc.subjectOral carcinogenesis
dc.subjectOral leukoplakia
dc.subjectOral premalignant disease
dc.titleClinical Management Update of Oral Leukoplakia: A Review From the American Head and Neck Society Cancer Prevention Service
dc.typeArticle
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