Efficacy of Dietary Interventions for Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis

dc.contributor.authorHaghbin, Hossein
dc.contributor.authorHasan, Fariha
dc.contributor.authorGangwani, Manesh Kumar
dc.contributor.authorZakirkhodjaev, Nurruddinkhodja
dc.contributor.authorLee-Smith, Wade
dc.contributor.authorBeran, Azizullah
dc.contributor.authorKamal, Faisal
dc.contributor.authorHart, Benjamin
dc.contributor.authorAziz, Muhammad
dc.contributor.departmentMedicine, School of Medicine
dc.date.accessioned2025-02-18T12:55:16Z
dc.date.available2025-02-18T12:55:16Z
dc.date.issued2024-12-11
dc.description.abstractIntroduction: Irritable bowel syndrome (IBS) is a common condition that alters the quality of life of patients. A variety of dietary interventions have been introduced to address this debilitating condition. The low-FODMAP diet (LFD), gluten-free diet (GFD), and Mediterranean diet are examples showing efficacy. The aim of this network meta-analysis was to compare these interventions to find the best approach. Methods: We performed a systematic review of the available literature through 14 March 2024 in the following databases: Embase, PubMed, MEDLINE OVID, Web of Science, CINAHL Plus, and Cochrane Central. We only included randomized controlled trials (RCTs). We used a random effects model and conducted a direct meta-analysis based on the DerSimonian-Laird approach and a network meta-analysis based on the frequentist approach. Mean differences (MDs) with 95% confidence interval (CI) were calculated. The primary outcomes included IBS quality of life (IBS QOL) and IBS symptom severity scale (IBS-SSS). Results: We finalized 23 studies including 1689 IBS patients. In the direct meta-analysis, there was no statistically significant difference in any IBS score between GFD and either LFD or standard diet. Meanwhile, the LFD was statistically superior to the standard diet in the IBS-SSS (MD: -46.29, CI: -63.72--28.86, p < 0.01) and IBS QOL (MD: 4.06, CI: 0.72-7.41, p = 0.02). On ranking, the Mediterranean diet showed the greatest improvement in IBS-SSS, IBS-QOL, distension, dissatisfaction, and general life interference, followed by the LFD alone or in combination with the GFD. Conclusions: We demonstrated the efficacy of dietary interventions such as the LFD and Mediterranean diet in improving IBS. There is a need for large RCTs with head-to-head comparisons, particularly for the Mediterranean diet.
dc.eprint.versionFinal published version
dc.identifier.citationHaghbin H, Hasan F, Gangwani MK, et al. Efficacy of Dietary Interventions for Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis. J Clin Med. 2024;13(24):7531. Published 2024 Dec 11. doi:10.3390/jcm13247531
dc.identifier.urihttps://hdl.handle.net/1805/45783
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isversionof10.3390/jcm13247531
dc.relation.journalJournal of Clinical Medicine
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.sourcePMC
dc.subjectGluten-free diet
dc.subjectIrritable bowel syndrome
dc.subjectLow-FODMAP diet
dc.subjectMediterranean diet
dc.titleEfficacy of Dietary Interventions for Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis
dc.typeArticle
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