Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis
dc.contributor.author | Amjad, Waseem | |
dc.contributor.author | Qureshi, Waqas | |
dc.contributor.author | Singh, Ritu R. | |
dc.contributor.author | Richter, Seth | |
dc.contributor.department | Medicine, School of Medicine | en_US |
dc.date.accessioned | 2023-04-04T13:49:08Z | |
dc.date.available | 2023-04-04T13:49:08Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Background: Gastroparesis is a debilitating condition that may impact morbidity and mortality, but there is a lack of long-term studies examining this relation. The aim of this study was to determine the predictors of mortality in gastroparesis and to determine the nutritional deficiencies. Methods: Between September 30, 2009 and January 31, 2020, we identified 320 patients (mean age 47.5±5.3 years, 70% female, 71.3% Whites, 39.7% diabetic and 60.3% nondiabetic) with gastroparesis. 99mTc sulfur-labeled food was used to diagnose gastroparesis. Cox proportional-hazard regression was used to compute the association of mortality predictors. Results: Of the 320 patients, 46 (14.4%) died during the study period. Among diabetics, advanced age (hazard ratio [HR] 1.06, 95% confidence interval [CI] 1.03-1.10; P<0.001), chronic kidney disease (CKD) (HR 4.69, 95%CI 1.62-13.59; P=0.004), and malnutrition (HR 10.95, 95%CI 3.23-37.17; P<0.001) were associated with higher mortality, whereas in nondiabetics older age (HR 1.05, 95%CI 1.01-1.09; P=0.04), CKD (HR 10.2, 95%CI 2.48-41.99; P=0.001), chronic obstructive pulmonary disease (COPD) (HR 7.5, 95%CI 2.11-26.82; P=0.002), coronary artery disease (CAD) (HR 9.7, 95%CI 1.8-52.21; P=0.008), and malnutrition (HR 3.83, 95%CI 1.14-29.07; P=0.03) were associated with increased mortality. Overall, 48.8% had vitamin D, 18.2% had vitamin B12, and 50.8% had iron deficiencies. Only 19.4% of the whole cohort was evaluated by a nutritionist. Conclusions: Advanced age, CAD, CKD, COPD and malnutrition were associated with higher mortality in gastroparesis. Despite the high prevalence of nutritional deficiencies, consultation of a specialist nutritionist was uncommon. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Amjad W, Qureshi W, Singh RR, Richter S. Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis. Ann Gastroenterol. 2021;34(6):788-795. doi:10.20524/aog.2021.0660 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/32213 | |
dc.language.iso | en_US | en_US |
dc.publisher | Hellenic Society of Gastroenterology | en_US |
dc.relation.isversionof | 10.20524/aog.2021.0660 | en_US |
dc.relation.journal | Annals of Gastroenterology | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.source | PMC | en_US |
dc.subject | Gastroparesis | en_US |
dc.subject | Diabetes mellitus | en_US |
dc.subject | Nutritional deficiencies | en_US |
dc.subject | Gastric emptying study | en_US |
dc.title | Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis | en_US |
dc.type | Article | en_US |