Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration

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dc.contributor.authorGanzen, Logan
dc.contributor.authorVenkatraman, Prahatha
dc.contributor.authorPang, Chi Pui
dc.contributor.authorLeung, Yuk Fai
dc.contributor.authorZhang, Mingzhi
dc.contributor.departmentBiochemistry and Molecular Biology, School of Medicineen_US
dc.date.accessioned2017-12-21T15:19:50Z
dc.date.available2017-12-21T15:19:50Z
dc.date.issued2017-06-02
dc.description.abstractZebrafish are a popular vertebrate model in drug discovery. They produce a large number of small and rapidly-developing embryos. These embryos display rich visual-behaviors that can be used to screen drugs for treating retinal degeneration (RD). RD comprises blinding diseases such as Retinitis Pigmentosa, which affects 1 in 4000 people. This disease has no definitive cure, emphasizing an urgency to identify new drugs. In this review, we will discuss advantages, challenges, and research developments in using zebrafish behaviors to screen drugs in vivo. We will specifically discuss a visual-motor response that can potentially expedite discovery of new RD drugs.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationGanzen, L., Venkatraman, P., Pang, C. P., Leung, Y. F., & Zhang, M. (2017). Utilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degeneration. International Journal of Molecular Sciences, 18(6), 1185. http://doi.org/10.3390/ijms18061185en_US
dc.identifier.urihttps://hdl.handle.net/1805/14858
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isversionof10.3390/ijms18061185en_US
dc.relation.journalInternational Journal of Molecular Sciencesen_US
dc.rightsAttribution 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/
dc.sourcePMCen_US
dc.subjectDrug screeningen_US
dc.subjectNight blindnessen_US
dc.subjectRetinal degenerationen_US
dc.subjectRetinitis pigmentosaen_US
dc.subjectVisual behaviorsen_US
dc.subjectVisual motor responseen_US
dc.subjectZebrafishen_US
dc.titleUtilizing Zebrafish Visual Behaviors in Drug Screening for Retinal Degenerationen_US
dc.typeArticleen_US
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