The first wave of B lymphopoiesis develops independently of stem cells in the murine embryo

dc.contributor.authorYoshimoto, Momoko
dc.contributor.departmentDepartment of Pediatrics, IU School of Medicineen_US
dc.date.accessioned2015-12-21T19:24:12Z
dc.date.available2015-12-21T19:24:12Z
dc.date.issued2015-02-01
dc.description.abstractIn the developing mouse embryo, there are several waves of hematopoiesis. Primitive and definitive erythromyeloid lineages appear prior to hematopoietic stem cell (HSC) emergence, and these waves are considered to be transient and support embryonic homeostasis until HSC-derived hematopoiesis is established. However, recent evidence strongly suggests that HSC-independent immune cells, such as tissue macrophages and some innate lymphoid cells, develop in the mouse embryo and persist into postnatal life. Innate type B-1 cells have also been reported to emerge from hemogenic endothelial cells in the extraembryonic yolk sac and para-aortic splanchnopleura, and continue to develop in the fetal liver, even in HSC-deficient mouse embryos. Here, this review discusses B-1 cell development in the context of the layered immune system hypothesis of B lymphopoiesis and the emergence of B-1 cells independent of HSCs.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationYoshimoto, M. (2015). The first wave of B lymphopoiesis develops independently of stem cells in the murine embryo. Annals of the New York Academy of Sciences, 2015 Dec;1362(1):16-22.http://doi.org/10.1111/nyas.12612en_US
dc.identifier.urihttps://hdl.handle.net/1805/7782
dc.language.isoen_USen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1111/nyas.12612en_US
dc.relation.journalAnnals of the New York Academy of Sciencesen_US
dc.rightsIUPUI Open Access Policyen_US
dc.sourceAuthoren_US
dc.subjectB-1en_US
dc.subjecthematopoietic stem cellsen_US
dc.subjectstem cellsen_US
dc.subjectmouse embryosen_US
dc.subjectB lymphopoiesisen_US
dc.titleThe first wave of B lymphopoiesis develops independently of stem cells in the murine embryoen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Yoshimoto-2015-the-first-wave.pdf
Size:
451.28 KB
Format:
Adobe Portable Document Format
Description:
Author's manuscript
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.88 KB
Format:
Item-specific license agreed upon to submission
Description: