White matter alterations in early-stage Alzheimer's disease: A tract-specific study

dc.contributor.authorWen, Qiuting
dc.contributor.authorMustafi, Sourajit M.
dc.contributor.authorLi, Junjie
dc.contributor.authorRisacher, Shannon L.
dc.contributor.authorTallman, Eileen
dc.contributor.authorBrown, Steven A.
dc.contributor.authorWest, John D.
dc.contributor.authorHarezlak, Jaroslaw
dc.contributor.authorFarlow, Martin R.
dc.contributor.authorUnverzagt, Frederick W.
dc.contributor.authorGao, Sujuan
dc.contributor.authorApostolova, Liana G.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorWu, Yu-Chien
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicineen_US
dc.date.accessioned2019-10-09T21:51:42Z
dc.date.available2019-10-09T21:51:42Z
dc.date.issued2019-08-21
dc.description.abstractIntroduction: Diffusion magnetic resonance imaging may allow for microscopic characterization of white matter degeneration in early stages of Alzheimer's disease. Methods: Multishell Diffusion magnetic resonance imaging data were acquired from 100 participants (40 cognitively normal, 38 with subjective cognitive decline, and 22 with mild cognitive impairment [MCI]). White matter microscopic degeneration in 27 major tracts of interest was assessed using diffusion tensor imaging (DTI), neurite orientation dispersion and density imaging, and q-space imaging. Results: Lower DTI fractional anisotropy and higher radial diffusivity were observed in the cingulum, thalamic radiation, and forceps major of participants with MCI. These tracts of interest also had the highest predictive power to discriminate groups. Diffusion metrics were associated with cognitive performance, particularly Rey Auditory Verbal Learning Test immediate recall, with the highest association observed in participants with MCI. Discussion: While DTI was the most sensitive, neurite orientation dispersion and density imaging and q-space imaging complementarily characterized reduced axonal density accompanied with dispersed and less restricted white matter microstructures.en_US
dc.identifier.citationWen, Q., Mustafi, S. M., Li, J., Risacher, S. L., Tallman, E., Brown, S. A., … Wu, Y. C. (2019). White matter alterations in early-stage Alzheimer's disease: A tract-specific study. Alzheimer's & dementia (Amsterdam, Netherlands), 11, 576–587. doi:10.1016/j.dadm.2019.06.003en_US
dc.identifier.urihttps://hdl.handle.net/1805/21073
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.dadm.2019.06.003en_US
dc.relation.journalAlzheimer's & Dementiaen_US
dc.rightsAttribution 4.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.sourcePMCen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectDiffusion imagingen_US
dc.subjectWhite matteren_US
dc.subjectTracten_US
dc.subjectTractographyen_US
dc.subjectDiffusion tensor imagingen_US
dc.subjectNODDIen_US
dc.subjectSCDen_US
dc.subjectMCIen_US
dc.titleWhite matter alterations in early-stage Alzheimer's disease: A tract-specific studyen_US
dc.typeArticleen_US
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