Sex differences in effects of tDCS and language treatments on brain functional connectivity in primary progressive aphasia
dc.contributor.author | Licata, Abigail E. | |
dc.contributor.author | Zhao, Yi | |
dc.contributor.author | Herrmann, Olivia | |
dc.contributor.author | Hillis, Argye E. | |
dc.contributor.author | Desmond, John | |
dc.contributor.author | Onyike, Chiadi | |
dc.contributor.author | Tsapkini, Kyrana | |
dc.contributor.department | Biostatistics, School of Public Health | |
dc.date.accessioned | 2023-10-17T15:37:04Z | |
dc.date.available | 2023-10-17T15:37:04Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Primary Progressive Aphasia (PPA) is a neurodegenerative disorder primarily affecting language functions. Neuromodulatory techniques (e.g., transcranial direct current stimulation, active-tDCS) and behavioral (speech-language) therapy have shown promising results in treating speech and language deficits in PPA patients. One mechanism of active-tDCS efficacy is through modulation of network functional connectivity (FC). It remains unknown how biological sex influences FC and active-tDCS or language treatment(s). In the current study, we compared sex differences, induced by active-tDCS and language therapy alone, in the default mode and language networks, acquired during resting-state fMRI in 36 PPA patients. Using a novel statistical method, the covariate-assisted-principal-regression (CAPs) technique, we found sex and age differences in FC changes following active-tDCS. In the default mode network (DMN): (1) men (in both conditions) showed greater FC in DMN than women. (2) men who received active-tDCS showed greater FC in the DMN than men who received language-treatment only. In the language network: (1) women who received active-tDCS showed significantly greater FC across the language network than women who received sham-tDCS. As age increases, regardless of sex and treatment condition, FC in language regions decreases. The current findings suggest active-tDCS treatment in PPA alters network-specific FC in a sex-dependent manner. | |
dc.eprint.version | Final published version | |
dc.identifier.citation | Licata AE, Zhao Y, Herrmann O, et al. Sex differences in effects of tDCS and language treatments on brain functional connectivity in primary progressive aphasia. Neuroimage Clin. 2023;37:103329. doi:10.1016/j.nicl.2023.103329 | |
dc.identifier.uri | https://hdl.handle.net/1805/36389 | |
dc.language.iso | en_US | |
dc.publisher | Elsevier | |
dc.relation.isversionof | 10.1016/j.nicl.2023.103329 | |
dc.relation.journal | NeuroImage: Clinical | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | PMC | |
dc.subject | Sex differences | |
dc.subject | Language therapy | |
dc.subject | Primary progressive aphasia (PPA) | |
dc.subject | Transcranial direct current stimulation (tDCS) | |
dc.subject | Functional connectivity | |
dc.title | Sex differences in effects of tDCS and language treatments on brain functional connectivity in primary progressive aphasia | |
dc.type | Article |