A Systematic Review of miR-29 in Cancer
dc.contributor.author | Kwon, Jason J. | |
dc.contributor.author | Factora, Tricia D. | |
dc.contributor.author | Dey, Shatovisha | |
dc.contributor.author | Kota, Janaiah | |
dc.contributor.department | Medical and Molecular Genetics, School of Medicine | en_US |
dc.date.accessioned | 2019-07-25T18:59:14Z | |
dc.date.available | 2019-07-25T18:59:14Z | |
dc.date.issued | 2018-12-31 | |
dc.description.abstract | MicroRNAs (miRNA) are small non-coding RNAs (∼22 nt in length) that are known as potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a critical role in cancer pathogenesis, and the misregulation of miRNAs is a well-known feature of cancer. In recent years, miR-29 has emerged as a critical miRNA in various cancers, and it has been shown to regulate multiple oncogenic processes, including epigenetics, proteostasis, metabolism, proliferation, apoptosis, metastasis, fibrosis, angiogenesis, and immunomodulation. Although miR-29 has been thoroughly documented as a tumor suppressor in the majority of studies, some controversy remains with conflicting reports of miR-29 as an oncogene. In this review, we provide a systematic overview of miR-29's functional role in various mechanisms of cancer and introspection on the contradictory roles of miR-29. | en_US |
dc.identifier.citation | Kwon, J. J., Factora, T. D., Dey, S., & Kota, J. (2018). A Systematic Review of miR-29 in Cancer. Molecular therapy oncolytics, 12, 173–194. doi:10.1016/j.omto.2018.12.011 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/19960 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.omto.2018.12.011 | en_US |
dc.relation.journal | Molecular Therapy Oncolytics | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/us | * |
dc.source | PMC | en_US |
dc.subject | MicroRNAs (miRNA) | en_US |
dc.subject | non-coding RNAs | en_US |
dc.subject | Eukaryotic gene expression | en_US |
dc.subject | miR-29 | en_US |
dc.subject | Oncogene | en_US |
dc.title | A Systematic Review of miR-29 in Cancer | en_US |
dc.type | Article | en_US |