A Systematic Review of miR-29 in Cancer

dc.contributor.authorKwon, Jason J.
dc.contributor.authorFactora, Tricia D.
dc.contributor.authorDey, Shatovisha
dc.contributor.authorKota, Janaiah
dc.contributor.departmentMedical and Molecular Genetics, School of Medicineen_US
dc.date.accessioned2019-07-25T18:59:14Z
dc.date.available2019-07-25T18:59:14Z
dc.date.issued2018-12-31
dc.description.abstractMicroRNAs (miRNA) are small non-coding RNAs (∼22 nt in length) that are known as potent master regulators of eukaryotic gene expression. miRNAs have been shown to play a critical role in cancer pathogenesis, and the misregulation of miRNAs is a well-known feature of cancer. In recent years, miR-29 has emerged as a critical miRNA in various cancers, and it has been shown to regulate multiple oncogenic processes, including epigenetics, proteostasis, metabolism, proliferation, apoptosis, metastasis, fibrosis, angiogenesis, and immunomodulation. Although miR-29 has been thoroughly documented as a tumor suppressor in the majority of studies, some controversy remains with conflicting reports of miR-29 as an oncogene. In this review, we provide a systematic overview of miR-29's functional role in various mechanisms of cancer and introspection on the contradictory roles of miR-29.en_US
dc.identifier.citationKwon, J. J., Factora, T. D., Dey, S., & Kota, J. (2018). A Systematic Review of miR-29 in Cancer. Molecular therapy oncolytics, 12, 173–194. doi:10.1016/j.omto.2018.12.011en_US
dc.identifier.urihttps://hdl.handle.net/1805/19960
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.omto.2018.12.011en_US
dc.relation.journalMolecular Therapy Oncolyticsen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/us*
dc.sourcePMCen_US
dc.subjectMicroRNAs (miRNA)en_US
dc.subjectnon-coding RNAsen_US
dc.subjectEukaryotic gene expressionen_US
dc.subjectmiR-29en_US
dc.subjectOncogeneen_US
dc.titleA Systematic Review of miR-29 in Canceren_US
dc.typeArticleen_US
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