Blood myo-inositol concentrations in preterm and term infants
| dc.contributor.author | Brion, Luc P. | |
| dc.contributor.author | Phelps, Dale L. | |
| dc.contributor.author | Ward, Robert M. | |
| dc.contributor.author | Nolen, Tracy L. | |
| dc.contributor.author | Hallman, N. Mikko K. | |
| dc.contributor.author | Das, Abhik | |
| dc.contributor.author | Zaccaro, Daniel J. | |
| dc.contributor.author | Ball, M. Bethany | |
| dc.contributor.author | Watterberg, Kristi L. | |
| dc.contributor.author | Frantz, Ivan D., III. | |
| dc.contributor.author | Cotten, C. Michael | |
| dc.contributor.author | Poindexter, Brenda B. | |
| dc.contributor.author | Oh, William | |
| dc.contributor.author | Lugo, Ralph A. | |
| dc.contributor.author | Van Meurs, Krisa P. | |
| dc.contributor.author | O’Shea, T. Michael | |
| dc.contributor.author | Zaterka-Baxter, Kristin M. | |
| dc.contributor.author | Higgins, Rosemary D. | |
| dc.contributor.department | Pediatrics, School of Medicine | en_US |
| dc.date.accessioned | 2022-05-17T13:05:24Z | |
| dc.date.available | 2022-05-17T13:05:24Z | |
| dc.date.issued | 2021-02 | |
| dc.description.abstract | Objective: To describe relationship between cord blood (representing fetal) myo-inositol concentrations and gestational age (GA) and to determine trends of blood concentrations in enterally and parenterally fed infants from birth to 70 days of age. Design/methods: Samples were collected in 281 fed or unfed infants born in 2005 and 2006. Myo-inositol concentrations were displayed in scatter plots and analyzed with linear regression models of natural log-transformed values. Results: In 441 samples obtained from 281 infants, myo-inositol concentrations varied from nondetectable to 1494 μmol/L. Cord myo-inositol concentrations decreased an estimated 11.9% per week increase in GA. Postnatal myo-inositol concentrations decreased an estimated 14.3% per week increase in postmenstrual age (PMA) and were higher for enterally fed infants compared to unfed infants (51% increase for fed vs. unfed infants). Conclusions: Fetal myo-inositol concentrations decreased with increasing GA. Postnatal concentrations decreased with increasing PMA and were higher among enterally fed than unfed infants. | en_US |
| dc.eprint.version | Author's manuscript | en_US |
| dc.identifier.citation | Brion LP, Phelps DL, Ward RM, et al. Blood myo-inositol concentrations in preterm and term infants. J Perinatol. 2021;41(2):247-254. doi:10.1038/s41372-020-00799-5 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1805/29035 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Springer Nature | en_US |
| dc.relation.isversionof | 10.1038/s41372-020-00799-5 | en_US |
| dc.relation.journal | Journal of Perinatology | en_US |
| dc.rights | Publisher Policy | en_US |
| dc.source | PMC | en_US |
| dc.subject | Fetal blood | en_US |
| dc.subject | Gestational age | en_US |
| dc.subject | Newborn infant | en_US |
| dc.subject | Inositol | en_US |
| dc.title | Blood myo-inositol concentrations in preterm and term infants | en_US |
| dc.type | Article | en_US |