Three-Year Survival after Transcatheter Aortic Valve Replacement: Findings from the Marshfield Aortic Valve Experience (MAVE) Study

dc.contributor.authorUmukoro, Peter E.
dc.contributor.authorYeung-Lai-Wah, Paul
dc.contributor.authorPathak, Sunil
dc.contributor.authorElkhidir, Sabri
dc.contributor.authorSoodi, Deepa
dc.contributor.authorDelgoffe, Brooke
dc.contributor.authorBerg, Richard
dc.contributor.authorAnderson, Kelley P.
dc.contributor.authorGarcia-Montilla, Romel J.
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2022-06-17T13:26:06Z
dc.date.available2022-06-17T13:26:06Z
dc.date.issued2021-03
dc.description.abstractBackground: Transcatheter aortic valve replacement (TAVR) is a rapidly evolving treatment for severe aortic stenosis. However, uncertainties exist for optimal valve selection as there are few long-term studies comparing patient survival by valve type.Objective: We hypothesized that self-expandable valves (SEV) would provide a survival advantage over balloon expandable valves (BEV), as SEV continue to expand and might better accommodate to the anatomy of the aortic valve over time.Methods: We examined outcomes according to valve type from a rural tertiary referral center between 2012 and 2017.Results: Out of 269 patients, 77 deaths (28.6%) occurred over the study period with 6 deaths by 1 month post-TAVR and 37 deaths by 1 year post-TAVR. The median observation time for survivors was 21.5 months. The probability of survival at 3 years was 60.7% and 61.9% for patients who underwent treatment with SEV and BEV, respectively. There was no statistically significant difference in overall patient survival with or without adjustment for factors such as age, sex, race, and aortic valve area. Additionally, in a secondary analysis restricted to those patients treated in later years (2015-2017) survival among patients with BEV appeared superior (HR=0.456, P=0.015).Conclusion: Patients who underwent TAVR at a rural medical center with SEV showed similar survival compared to those who received a BEV. Superior survival was observed among those who received BEV versus SEV between 2015 and 2017.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationUmukoro PE, Yeung-Lai-Wah P, Pathak S, et al. Three-Year Survival after Transcatheter Aortic Valve Replacement: Findings from the Marshfield Aortic Valve Experience (MAVE) Study. Clin Med Res. 2021;19(1):10-18. doi:10.3121/cmr.2020.1539en_US
dc.identifier.urihttps://hdl.handle.net/1805/29363
dc.language.isoen_USen_US
dc.publisherMarshfield Clinicen_US
dc.relation.isversionof10.3121/cmr.2020.1539en_US
dc.relation.journalClinical Medicine & Researchen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectTAVRen_US
dc.subjectMortalityen_US
dc.subjectAortic stenosisen_US
dc.titleThree-Year Survival after Transcatheter Aortic Valve Replacement: Findings from the Marshfield Aortic Valve Experience (MAVE) Studyen_US
dc.typeArticleen_US
ul.alternative.fulltexthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7987094/en_US
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