White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

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dc.contributor.authorLee, Seonjoo
dc.contributor.authorViqar, Fawad
dc.contributor.authorZimmerman, Molly E.
dc.contributor.authorNarkhede, Atul
dc.contributor.authorTosto, Giuseppe
dc.contributor.authorBenzinger, Tammie L.S.
dc.contributor.authorMarcus, Daniel S.
dc.contributor.authorFagan, Anne M.
dc.contributor.authorGoate, Alison
dc.contributor.authorFox, Nick C.
dc.contributor.authorCairns, Nigel J.
dc.contributor.authorHoltzman, David M.
dc.contributor.authorBuckles, Virginia
dc.contributor.authorGhetti, Bernardino
dc.contributor.authorMcDade, Eric
dc.contributor.authorMartins, Ralph N.
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorMasters, Colin L.
dc.contributor.authorRingman, John M.
dc.contributor.authorRyan, Natalie S.
dc.contributor.authorFörster, Stefan
dc.contributor.authorLaske, Christoph
dc.contributor.authorSchofield, Peter R.
dc.contributor.authorSperling, Reisa A.
dc.contributor.authorSalloway, Stephen
dc.contributor.authorCorreia, Stephen
dc.contributor.authorJack, Clifford
dc.contributor.authorWeiner, Michael
dc.contributor.authorBateman, Randall J.
dc.contributor.authorMorris, John C.
dc.contributor.authorMayeux, Richard
dc.contributor.authorBrickman, Adam M.
dc.contributor.authorDominantly Inherited Alzheimer Network
dc.contributor.departmentDepartment of Pathology and Laboratory Medicine, School of Medicineen_US
dc.date.accessioned2017-10-20T14:28:10Z
dc.date.available2017-10-20T14:28:10Z
dc.date.issued2016-06
dc.description.abstractWhite matter hyperintensities (WMHs) are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascular disease. Increased WMH volume is associated with risk and progression of Alzheimer's disease (AD). These observations are typically interpreted as evidence that vascular abnormalities play an additive, independent role contributing to symptom presentation, but not core features of AD. We examined the severity and distribution of WMH in presymptomatic PSEN1, PSEN2, and APP mutation carriers to determine the extent to which WMH manifest in individuals genetically determined to develop AD.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationLee, S., Viqar, F., Zimmerman, M. E., Narkhede, A., Tosto, G., Benzinger, T. L.S., Marcus, D. S., Fagan, A. M., Goate, A., Fox, N. C., Cairns, N. J., Holtzman, D. M., Buckles, V., Ghetti, B., McDade, E., Martins, R. N., Saykin, A. J., Masters, C. L., Ringman, J. M., Ryan, N. S., Förster, S., Laske, C., Schofield, P. R., Sperling, R. A., Salloway, S., Correia, S., Jack, C., Weiner, M., Bateman, R. J., Morris, J. C., Mayeux, R., Brickman, A. M. and for the Dominantly Inherited Alzheimer Network (2016), White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network. Ann Neurol., 79: 929–939. doi:10.1002/ana.24647en_US
dc.identifier.urihttps://hdl.handle.net/1805/14347
dc.language.isoen_USen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/ana.24647en_US
dc.relation.journalAnnals of Neurologyen_US
dc.rightsPublisher Policy
dc.sourcePMCen_US
dc.subjectAlzheimer's diseaseen_US
dc.titleWhite matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer networken_US
dc.typeArticleen_US
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