Height, nevus count, and risk of cutaneous malignant melanoma: Results from 2 large cohorts of US women
dc.contributor.author | Li, Xin | |
dc.contributor.author | Kraft, Peter | |
dc.contributor.author | De Vivo, Immaculata | |
dc.contributor.author | Giovannucci, Edward | |
dc.contributor.author | Liang, Liming | |
dc.contributor.author | Nan, Hongmei | |
dc.contributor.department | Epidemiology, School of Public Health | en_US |
dc.date.accessioned | 2023-07-10T15:11:26Z | |
dc.date.available | 2023-07-10T15:11:26Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Background: Taller individuals are at higher risk of melanoma. Objective: To prospectively investigate the association of height with nevus count and melanoma and estimate the proportion of height-melanoma association explained by nevus count among white participants from the Nurses' Health Study (NHS) and Nurses' Health Study 2 (NHS2). Methods: We used Cox proportional hazards regression and multinomial logistic regression for data analyses, with adjustment of potential confounders in the multivariate model. Results: We included 82,468 and 106,069 women from NHS and NHS2, respectively. The hazard ratio was 1.21 (95% confidence interval [CI] 1.12-1.31) for the association between every 10-cm increase in height and melanoma. Compared with women with no nevi, the odds ratios (95% CIs) associated with a 10-cm increase in height were 1.35 (95% CI 1.23-1.48) in the NHS and 1.12 (95% CI 1.09-1.15) in the NHS2 for women with greater than or equal to 10 moles. The proportion of excess melanoma risk associated with each 10-cm increase in height explained by nevus count was 8.03% in the NHS and 10.22% in the NHS2. Limitation: Self-reported height and nevus count. Mole counts were limited to 1 arm or both legs. Conclusion: Nevus count is an important explanatory factor for the excess risk of melanoma among taller white women. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Li X, Kraft P, De Vivo I, Giovannucci E, Liang L, Nan H. Height, nevus count, and risk of cutaneous malignant melanoma: Results from 2 large cohorts of US women. J Am Acad Dermatol. 2020;83(4):1049-1056. doi:10.1016/j.jaad.2020.04.158 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/34282 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.jaad.2020.04.158 | en_US |
dc.relation.journal | Journal of the American Academy of Dermatology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Height | en_US |
dc.subject | Nevus count | en_US |
dc.subject | Cutaneous melanoma | en_US |
dc.subject | Prospective cohorts | en_US |
dc.title | Height, nevus count, and risk of cutaneous malignant melanoma: Results from 2 large cohorts of US women | en_US |
dc.type | Article | en_US |