SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells

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dc.contributor.authorZhong, Xiaolin
dc.contributor.authorHuang, Menghao
dc.contributor.authorKim, Hyeong-Geug
dc.contributor.authorZhang, Yang
dc.contributor.authorChowdhury, Kushan
dc.contributor.authorCai, Wenjie
dc.contributor.authorSaxena, Romil
dc.contributor.authorSchwabe, Robert F.
dc.contributor.authorLiangpunsakul, Suthat
dc.contributor.authorDong, X. Charlie
dc.contributor.departmentBiochemistry and Molecular Biology, School of Medicineen_US
dc.date.accessioned2020-11-18T16:25:00Z
dc.date.available2020-11-18T16:25:00Z
dc.date.issued2020-04-17
dc.identifier.citationZhong, X., Huang, M., Kim, H.-G., Zhang, Y., Chowdhury, K., Cai, W., Saxena, R., Schwabe, R. F., Liangpunsakul, S., & Dong, X. C. (2020). SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells. Cellular and Molecular Gastroenterology and Hepatology, 10(2), 341–364. https://doi.org/10.1016/j.jcmgh.2020.04.005en_US
dc.identifier.issn2352-345Xen_US
dc.identifier.urihttps://hdl.handle.net/1805/24446
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.jcmgh.2020.04.005en_US
dc.relation.journalCellular and Molecular Gastroenterology and Hepatologyen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.sourcePMCen_US
dc.subjectalanine aminotransferaseen_US
dc.subjectchromatin immunoprecipitationen_US
dc.subjectDulbecco’s modified Eagle mediumen_US
dc.subjectgreen fluorescent proteinen_US
dc.subjecthemagglutininen_US
dc.subjecthepatic stellate cellen_US
dc.subjectKO knockouten_US
dc.subjectLratlecithin retinol acylen_US
dc.subjecttransferasemen_US
dc.subjectRNA messengeren_US
dc.subjectNAFLD nonalcoholic fatty liver diseaseen_US
dc.subjectNASH nonalcoholic steatohepatitisen_US
dc.subjectPBS phosphate-buffered salineen_US
dc.subjectPCR polymerase chain reactionsen_US
dc.subjecthRNA short hairpin RNAen_US
dc.subjectSIRT6 sirtuin 6en_US
dc.subjectSMAD3 SMAD family member 3en_US
dc.subjecttransgenicen_US
dc.subjecttransforming growth factor βen_US
dc.subjectWestern dieten_US
dc.subjectwild-typeen_US
dc.titleSIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cellsen_US
dc.typeArticleen_US
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