Effects of adolescent substance use disorders on central cholinergic function

dc.contributor.authorHauser, S.R.
dc.contributor.authorRodd, Z.A.
dc.contributor.authorDeehan, G.A.
dc.contributor.authorLiang, T.
dc.contributor.authorRahman, Shafiqur
dc.contributor.authorBell, Richard L.
dc.contributor.departmentPsychiatry, School of Medicine
dc.date.accessioned2023-07-21T16:51:07Z
dc.date.available2023-07-21T16:51:07Z
dc.date.issued2021
dc.description.abstractAdolescence is a transitional period between childhood and adulthood, in which the individual undergoes significant cognitive, behavioral, physical, emotional, and social developmental changes. During this period, adolescents engage in experimentation and risky behaviors such as licit and illicit drug use. Adolescents' high vulnerability to abuse drugs and natural reinforcers leads to greater risk for developing substance use disorders (SUDs) during adulthood. Accumulating evidence indicates that the use and abuse of licit and illicit drugs during adolescence and emerging adulthood can disrupt the cholinergic system and its processes. This review will focus on the effects of peri-adolescent nicotine and/or alcohol use, or exposure, on the cholinergic system during adulthood from preclinical and clinical studies. This review further explores potential cholinergic agents and pharmacological manipulations to counteract peri-adolescent nicotine and/or alcohol abuse.
dc.eprint.versionFinal published version
dc.identifier.citationHauser, S. R., Rodd, Z. A., Deehan, G. A., Liang, T., Rahman, S., & Bell, R. L. (2021). Effects of adolescent substance use disorders on central cholinergic function. International Review of Neurobiology, 160, 175–221. https://doi.org/10.1016/bs.irn.2021.07.008
dc.identifier.doi10.1016/bs.irn.2021.07.008
dc.identifier.isbn9780128208052
dc.identifier.issn0074-7742
dc.identifier.urihttps://hdl.handle.net/1805/34536
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Review of Neurobiology
dc.relation.ispartofEffects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part I
dc.relation.isversionof10.1016/bs.irn.2021.07.008
dc.relation.journalInternational Review of Neurobiology
dc.rightsPublisher Policy
dc.sourceAuthor
dc.subjectsubstance use disorders
dc.subjectadolescent
dc.subjectcentral cholinergic function
dc.titleEffects of adolescent substance use disorders on central cholinergic function
dc.typeArticle
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