The Dichotomy of Interleukin-9 Function in the Tumor Microenvironment
dc.contributor.author | Cannon, Anthony | |
dc.contributor.author | Pajulas, Abigail | |
dc.contributor.author | Kaplan, Mark H. | |
dc.contributor.author | Zhang, Jilu | |
dc.contributor.department | Microbiology and Immunology, School of Medicine | |
dc.date.accessioned | 2024-08-23T10:18:52Z | |
dc.date.available | 2024-08-23T10:18:52Z | |
dc.date.issued | 2023 | |
dc.description.abstract | Interleukin 9 (IL-9) is a cytokine with potent proinflammatory properties that plays a central role in pathologies such as allergic asthma, immunity to parasitic infection, and autoimmunity. More recently, IL-9 has garnered considerable attention in tumor immunity. Historically, IL-9 has been associated with a protumor function in hematological malignancies and an antitumor function in solid malignancies. However, recent discoveries of the dynamic role of IL-9 in cancer progression suggest that IL-9 can act as both a pro- or antitumor factor in various hematological and solid malignancies. This review summarizes IL-9-dependent control of tumor growth, regulation, and therapeutic applicability of IL-9 blockade and IL-9-producing cells in cancer. | |
dc.eprint.version | Final published version | |
dc.identifier.citation | Cannon A, Pajulas A, Kaplan MH, Zhang J. The Dichotomy of Interleukin-9 Function in the Tumor Microenvironment. J Interferon Cytokine Res. 2023;43(6):229-245. doi:10.1089/jir.2023.0035 | |
dc.identifier.uri | https://hdl.handle.net/1805/42902 | |
dc.language.iso | en_US | |
dc.publisher | Mary Ann Liebert | |
dc.relation.isversionof | 10.1089/jir.2023.0035 | |
dc.relation.journal | Journal of Interferon & Cytokine Research | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | IL-9 | |
dc.subject | Cancer | |
dc.subject | Cytokine | |
dc.subject | Immunotherapy | |
dc.subject | Tumor immunity | |
dc.subject | Tumor microenvironment | |
dc.title | The Dichotomy of Interleukin-9 Function in the Tumor Microenvironment | |
dc.type | Article | |
ul.alternative.fulltext | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282829/ |