Incidence of pathologic postobstructive diuresis after resolution of ureteropelvic junction obstruction with a normal contralateral kidney

dc.contributor.authorRoth, Joshua D.
dc.contributor.authorLesier, Jeffrey D.
dc.contributor.authorCasey, Jessica T.
dc.contributor.authorSzymanski, Konrad M.
dc.contributor.authorWhittam, Benjamin M.
dc.contributor.authorMisseri, Rosalia
dc.contributor.authorRink, Richard C.
dc.contributor.authorCain, Mark P.
dc.contributor.departmentPediatrics, School of Medicineen_US
dc.date.accessioned2018-09-17T20:05:59Z
dc.date.available2018-09-17T20:05:59Z
dc.date.issued2018
dc.description.abstractIntroduction Postobstructive diuresis (POD) after unilateral pyeloplasty or percutaneous nephrostomy (PCN) tube insertion for ureteropelvic junction obstruction (UPJO) in patients with a normal contralateral kidney is not well described. Objective The objective of this study was to determine the incidence and characteristics of POD after relief of unilateral UPJO in patients with a normal contralateral kidney. Study design Children who underwent a unilateral pyeloplasty or PCN for UPJO from 2010 to 2017 with a normal contralateral kidney were retrospectively reviewed. Postobstructive diuresis was defined as urine output (UO) of >300% of expected UO. Patients with a solitary kidney or those who underwent bilateral pyeloplasty or bilateral PCN tube placement were excluded. Results Out of 396 children meeting inclusion criteria, seven (1.8%) developed POD (4 after pyeloplasty and 3 after PCN tube placement). Median age at intervention was 1.7 years (range 11 days–18 years); median weight was 11.4 kg (range 3.7–54.2 kg). Postobstructive diuresis was more likely to occur in patients with grade 4 hydronephrosis (3.0%) and larger kidneys and if a PCN tube was placed before pyeloplasty. There was no significant difference in age, gender, kidney laterality, or function between those who developed POD and those who did not. Postobstructive diuresis was managed with additional intravenous fluids and electrolyte monitoring. Median initial postprocedure UO was 5.9 mg/kg/hr (range 3.2–10.0 mg/kg/hr). In five children who underwent PCN in whom UO could be differentiated between kidneys, median initial postprocedure UO was 6.1 mg/kg/hr (range 2.5–9.1 mg/kg/hr) from the affected side and 0.8 mg/kg/hr (range 0.4–0.9 mg/kg/hr) from the unaffected side. The median length of time to resolution of POD was 3 days (range 2–4 days). One patient developed significant acidosis and lethargy that improved with intravenous fluid management. Mild hyponatremia developed in two, hypokalemia in one, hypophosphatemia in one, acidosis in one, and hypoglycemia in 1 patient. Discussion A low but clinically significant risk of POD occurring after relief of unilateral UPJO in children with a normal contralateral kidney is described. Limitations include retrospective analysis and small sample size due to the rarity of the condition. Conclusion Postobstructive diuresis after decompression of UPJO in patients with a normal contralateral kidney is a rare event (1.8%). However, POD does occur, and patients should be carefully monitored after these procedures given the potential for significant dehydration and electrolyte disturbances.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationRoth, J. D., Lesier, J. D., Casey, J. T., Szymanski, K. M., Whittam, B. M., Misseri, R., … Cain, M. P. (2018). Incidence of pathologic postobstructive diuresis after resolution of ureteropelvic junction obstruction with a normal contralateral kidney. Journal of Pediatric Urology. https://doi.org/10.1016/j.jpurol.2018.07.012en_US
dc.identifier.urihttps://hdl.handle.net/1805/17334
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.jpurol.2018.07.012en_US
dc.relation.journalJournal of Pediatric Urologyen_US
dc.rightsPublisher Policyen_US
dc.sourceAuthoren_US
dc.subjectpyeloplastyen_US
dc.subjectpostobstructive diuresisen_US
dc.subjecthydronephrosisen_US
dc.titleIncidence of pathologic postobstructive diuresis after resolution of ureteropelvic junction obstruction with a normal contralateral kidneyen_US
dc.typeArticleen_US
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