The Genetic Architecture of the Human Cerebral Cortex

Simple item page
dc.contributor.authorGrasby, Katrina L.
dc.contributor.authorJahanshad, Neda
dc.contributor.authorPainter, Jodie N.
dc.contributor.authorColodro-Conde, Lucía
dc.contributor.authorBralten, Janita
dc.contributor.authorHibar, Derrek P.
dc.contributor.authorLind, Penelope A.
dc.contributor.authorPizzagalli, Fabrizio
dc.contributor.authorChing, Christopher R.K.
dc.contributor.authorMcMahon, Mary Agnes B.
dc.contributor.authorShatokhina, Natalia
dc.contributor.authorZsembik, Leo C.P.
dc.contributor.authorThomopoulos, Sophia I.
dc.contributor.authorZhu, Alyssa H.
dc.contributor.authorStrike, Lachlan T.
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorAlhusaini, Saud
dc.contributor.authorAlmeida, Marcio A.A.
dc.contributor.authorAlnæs, Dag
dc.contributor.authorAmlien, Inge K.
dc.contributor.authorAndersson, Micael
dc.contributor.authorArd, Tyler
dc.contributor.authorArmstrong, Nicola J.
dc.contributor.authorAshley-Koch, Allison
dc.contributor.authorAtkins, Joshua R.
dc.contributor.authorBernard, Manon
dc.contributor.authorBrouwer, Rachel M.
dc.contributor.authorBuimer, Elizabeth E.L.
dc.contributor.authorBülow, Robin
dc.contributor.authorBürger, Christian
dc.contributor.authorCannon, Dara M.
dc.contributor.authorChakravarty, Mallar
dc.contributor.authorChen, Qiang
dc.contributor.authorCheung, Joshua W.
dc.contributor.authorCouvy-Duchesne, Baptiste
dc.contributor.authorDale, Anders M.
dc.contributor.authorDalvie, Shareefa
dc.contributor.authorde Araujo, Tânia K.
dc.contributor.authorde Zubicaray, Greig I.
dc.contributor.authorde Zwarte, Sonja M.C.
dc.contributor.authorden Braber, Anouk
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorDohm, Katharina
dc.contributor.authorEhrlich, Stefan
dc.contributor.authorEngelbrecht, Hannah-Ruth
dc.contributor.authorErk, Susanne
dc.contributor.authorFan, Chun Chieh
dc.contributor.authorFedko, Iryna O.
dc.contributor.authorFoley, Sonya F.
dc.contributor.authorFord, Judith M.
dc.contributor.authorFukunaga, Masaki
dc.contributor.authorGarrett, Melanie E.
dc.contributor.authorGe, Tian
dc.contributor.authorGiddaluru, Sudheer
dc.contributor.authorGoldman, Aaron L.
dc.contributor.authorGreen, Melissa J.
dc.contributor.authorGroenewold, Nynke A.
dc.contributor.authorGrotegerd, Dominik
dc.contributor.authorGurholt, Tiril P.
dc.contributor.authorGutman, Boris A.
dc.contributor.authorHansell, Narelle K.
dc.contributor.authorHarris, Mathew A.
dc.contributor.authorHarrison, Marc B.
dc.contributor.authorHaswell, Courtney C.
dc.contributor.authorHauser, Michael
dc.contributor.authorHerms, Stefan
dc.contributor.authorHeslenfeld, Dirk J.
dc.contributor.authorHo, New Fei
dc.contributor.authorHoehn, David
dc.contributor.authorHoffmann, Per
dc.contributor.authorHolleran, Laurena
dc.contributor.authorHoogman, Martine
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorIkeda, Masashi
dc.contributor.authorJanowitz, Deborah
dc.contributor.authorJansen, Iris E.
dc.contributor.authorJia, Tianye
dc.contributor.authorJockwitz, Christiane
dc.contributor.authorKanai, Ryota
dc.contributor.authorKarama, Sherif
dc.contributor.authorKasperaviciute, Dalia
dc.contributor.authorKaufmann, Tobias
dc.contributor.authorKelly, Sinead
dc.contributor.authorKikuchi, Masataka
dc.contributor.authorKlein, Marieke
dc.contributor.authorKnapp, Michael
dc.contributor.authorKnodt, Annchen R.
dc.contributor.authorKrämer, Bernd
dc.contributor.authorLam, Max
dc.contributor.authorLancaster, Thomas M.
dc.contributor.authorLee, Phil H.
dc.contributor.authorLett, Tristram A.
dc.contributor.authorLewis, Lindsay B.
dc.contributor.authorLopes-Cendes, Iscia
dc.contributor.authorLuciano, Michelle
dc.contributor.authorMacciardi, Fabio
dc.contributor.authorMarquand, Andre F.
dc.contributor.authorMathias, Samuel R.
dc.contributor.authorMelzer, Tracy R.
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorMirza-Schreiber, Nazanin
dc.contributor.authorMoreira, Jose C.V.
dc.contributor.authorMühleisen, Thomas W.
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorNajt, Pablo
dc.contributor.authorNakahara, Soichiro
dc.contributor.authorNho, Kwangsik
dc.contributor.authorlde Loohuis, Loes M.O.
dc.contributor.authorOrfanos, Dimitri Papadopoulos
dc.contributor.authorPearson, John F.
dc.contributor.authorPitcher, Toni L.
dc.contributor.authorPütz, Benno
dc.contributor.authorQuidé, Yann
dc.contributor.authorRagothaman, Anjanibhargavi
dc.contributor.authorRashid, Faisal M.
dc.contributor.authorReay, William R.
dc.contributor.authorRedlich, Ronny
dc.contributor.authorReinbold, Céline S.
dc.contributor.authorRepple, Jonathan
dc.contributor.authorRichard, Geneviève
dc.contributor.authorRiedel, Brandalyn C.
dc.contributor.authorRisacher, Shannon L.
dc.contributor.authorRocha, Cristiane S.
dc.contributor.authorRoth Mota, Nina
dc.contributor.authorSalminen, Lauren
dc.contributor.authorSaremi, Arvin
dc.contributor.authorSaykin, Andrew J.
dc.contributor.authorSchlag, Fenja
dc.contributor.authorSchmaal, Lianne
dc.contributor.authorSchofield, Peter R.
dc.contributor.authorSecolin, Rodrigo
dc.contributor.authorShapland, Chin Yang
dc.contributor.authorShen, Li
dc.contributor.authorShin, Jean
dc.contributor.authorShumskaya, Elena
dc.contributor.authorSønderby, Ida E.
dc.contributor.authorSprooten, Emma
dc.contributor.authorTansey, Katherine E.
dc.contributor.authorTeumer, Alexander
dc.contributor.authorThalamuthu, Anbupalam
dc.contributor.authorTordesillas-Gutiérrez, Diana
dc.contributor.authorTurner, Jessica A.
dc.contributor.authorUhlmann, Anne
dc.contributor.authorVallerga, Costanza Ludovica
dc.contributor.authorvan der Meer, Dennis
dc.contributor.authorvan Donkelaar, Marjolein M.J.
dc.contributor.authorvan Eijk, Liza
dc.contributor.authorvan Erp, Theo G.M.
dc.contributor.authorvan Haren, Neeltje E.M.
dc.contributor.authorvan Rooij, Daan
dc.contributor.authorvan Tol, Marie-José
dc.contributor.authorVeldink, Jan H.
dc.contributor.authorVerhoef, Ellen
dc.contributor.authorWalton, Esther
dc.contributor.authorWang, Mingyuan
dc.contributor.authorWang, Yunpeng
dc.contributor.authorWardlaw, Joanna M.
dc.contributor.authorWen, Wei
dc.contributor.authorWestlye, Lars T.
dc.contributor.authorWhelan, Christopher D.
dc.contributor.authorWitt, Stephanie H.
dc.contributor.authorWittfeld, Katharina
dc.contributor.authorWolf, Christiane
dc.contributor.authorWolfers, Thomas
dc.contributor.authorWu, Jing Qin
dc.contributor.authorYasuda, Clarissa L.
dc.contributor.authorZaremba, Dario
dc.contributor.authorZhang, Zuo
dc.contributor.authorZwiers, Marcel P.
dc.contributor.authorArtiges, Eric
dc.contributor.authorAssareh, Amelia A.
dc.contributor.authorAyesa-Arriol, Rosa
dc.contributor.authorBelger, Aysenil
dc.contributor.authorBrandt, Christine L.
dc.contributor.authorBrown, Gregory G.
dc.contributor.authorCichon, Sven
dc.contributor.authorCurran, Joanne E.
dc.contributor.authorDavies, Gareth E.
dc.contributor.authorDegenhard, Franziska
dc.contributor.authorDennis, Michelle F.
dc.contributor.authorDietsche, Bruno
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorDoherty, Colin P.
dc.contributor.authorEspiritu, Ryan
dc.contributor.authorGarijo, Daniel
dc.contributor.authorGil, Yolanda
dc.contributor.authorGowland, Penny A.
dc.contributor.authorGreen, Robert C.
dc.contributor.authorHäusler, Alexander N.
dc.contributor.authorHeindel, Walter
dc.contributor.authorHo, Beng-Choon
dc.contributor.authorHoffmann, Wolfgang U.
dc.contributor.authorHolsboer, Florian
dc.contributor.authorHomuth, Georg
dc.contributor.authorHosten, Norbert
dc.contributor.authorJack, Clifford R.,Jr.
dc.contributor.authorJang, MiHyun
dc.contributor.authorJansen, Andreas
dc.contributor.authorKimbrel, Nathan A.
dc.contributor.authorKolskår, Knut
dc.contributor.authorKoops, Sanne
dc.contributor.authorKrug, Axel
dc.contributor.authorLim, Kelvin O.
dc.contributor.authorLuykx, Jurjen J.
dc.contributor.authorMathalon, Daniel H.
dc.contributor.authorMather, Karen A.
dc.contributor.authorMattay, Venkata S.
dc.contributor.authorMatthews, Sarah
dc.contributor.authorMayoral Van Son, Jaqueline
dc.contributor.authorMcEwen, Sarah C.
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMorris, Derek W.
dc.contributor.authorMueller, Bryon A.
dc.contributor.authorNauck, Matthias
dc.contributor.authorNordvik, Jan E.
dc.contributor.authorNöthen, Markus M.
dc.contributor.authorO'Leary, Daniel S.
dc.contributor.authorOpel, Nils
dc.contributor.authorPaillère Martinot, Marie-Laure
dc.contributor.authorPike, G. Bruce
dc.contributor.authorPreda, Adrian
dc.contributor.authorQuinlan, Erin B.
dc.contributor.authorRasser, Paul E.
dc.contributor.authorRatnakar, Varun
dc.contributor.authorReppermund, Simone
dc.contributor.authorSteen, Vidar M.
dc.contributor.authorTooney, Paul A.
dc.contributor.authorTorres, Fábio R.
dc.contributor.authorVeltman, Dick J.
dc.contributor.authorVoyvodic, James T.
dc.contributor.authorWhelan, Robert
dc.contributor.authorWhite, Tonya
dc.contributor.authorYamamori, Hidenaga
dc.contributor.authorAdams, Hieab H.H.
dc.contributor.authorBis, Joshua C.
dc.contributor.authorDebette, Stephanie
dc.contributor.authorDecarli, Charles
dc.contributor.authorFornage, Myriam
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHofer, Edith
dc.contributor.authorIkram, M. Arfan
dc.contributor.authorLauner, Lenore
dc.contributor.authorLongstreth, W.T.
dc.contributor.authorLopez, Oscar L.
dc.contributor.authorMazoyer, Bernard
dc.contributor.authorMosley, Thomas H.
dc.contributor.authorRoshchupkin, Gennady V.
dc.contributor.authorSatizabal, Claudia L.
dc.contributor.authorSchmidt, Reinhold
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorYang, Qiong
dc.contributor.authorAlvim, Marina K.M.
dc.contributor.authorAmes, David
dc.contributor.authorAnderson, Tim J.
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorArias-Vasquez, Alejandro
dc.contributor.authorBastin, Mark E.
dc.contributor.authorBaune, Bernhard T.
dc.contributor.authorBeckham, Jean C.
dc.contributor.authorBlangero, John
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorBrodaty, Henry
dc.contributor.authorBrunner, Han G.
dc.contributor.authorBuckner, Randy L.
dc.contributor.authorBuitelaar, Jan K.
dc.contributor.authorBustillo, Juan R.
dc.contributor.authorCahn, Wiepke
dc.contributor.authorCairns, Murray J.
dc.contributor.authorCalhoun, Vince
dc.contributor.authorCarr, Vaughan J.
dc.contributor.authorCaseras, Xavier
dc.contributor.authorCaspers, Svenja
dc.contributor.authorCavalleri, Gianpiero L.
dc.contributor.authorCendes, Fernando
dc.contributor.authorCorvin, Aiden
dc.contributor.authorCrespo-Facorro, Benedicto
dc.contributor.authorDalrymple-Alford, John C.
dc.contributor.authorDannlowski, Udo
dc.contributor.authorde Geus, Eco J.C.
dc.contributor.authorDeary, Ian J.
dc.contributor.authorDelanty, Norman
dc.contributor.authorDepondt, Chantal
dc.contributor.authorDesrivières, Sylvane
dc.contributor.authorDonohoe, Gary
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorFernández, Guillén
dc.contributor.authorFisher, Simon E.
dc.contributor.authorFlor, Herta
dc.contributor.authorForstner, Andreas J.
dc.contributor.authorFrancks, Clyde
dc.contributor.authorFranke, Barbara
dc.contributor.authorGlahn, David C.
dc.contributor.authorGollub, Randy L.
dc.contributor.authorGrabe, Hans J.
dc.contributor.authorGruber, Oliver
dc.contributor.authorHåberg, Asta K.
dc.contributor.authorHariri, Ahmad R.
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorHashimoto, Ryota
dc.contributor.authorHeinz, Andreas
dc.contributor.authorHenskens, Frans A.
dc.contributor.authorHillegers, Manon H.J.
dc.contributor.authorHoekstra, Pieter J.
dc.contributor.authorHolmes, Avram J.
dc.contributor.authorHong, L. Elliot
dc.contributor.authorHopkins, William D.
dc.contributor.authorHulshoff Pol, Hilleke E.
dc.contributor.authorJernigan, Terry L.
dc.contributor.authorJönsson, Erik G.
dc.contributor.authorKahn, René S.
dc.contributor.authorKennedy, Martin A.
dc.contributor.authorKircher, Tilo T.J.
dc.contributor.authorKochunov, Peter
dc.contributor.authorKwok, John B.J.
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorLoughland, Carmel M.
dc.contributor.authorMartin, Nicholas G.
dc.contributor.authorMartinot, Jean-Luc
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMcMahon, Katie L.
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.contributor.authorMichie, Patricia T.
dc.contributor.authorMorey, Rajendra A.
dc.contributor.authorMowry, Bryan
dc.contributor.authorNyberg, Lars
dc.contributor.authorOosterlaan, Jaap
dc.contributor.authorOphoff, Roel A.
dc.contributor.authorPantelis, Christos
dc.contributor.authorPaus, Tomas
dc.contributor.authorPausova, Zdenka
dc.contributor.authorPenninx, Brenda W.J.H.
dc.contributor.authorPolderman, Tinca J.C.
dc.contributor.authorPosthuma, Danielle
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRoffman, Joshua L.
dc.contributor.authorRowland, Laura M.
dc.contributor.authorSachdev, Perminder S.
dc.contributor.authorSämann, Philipp G.
dc.contributor.authorSchall, Ulrich
dc.contributor.authorSchumann, Gunter
dc.contributor.authorScott, Rodney J.
dc.contributor.authorSim, Kang
dc.contributor.authorSisodiya, Sanjay M.
dc.contributor.authorSmoller, Jordan W.
dc.contributor.authorSommer, Iris E.
dc.contributor.authorSt. Pourcain, Beate
dc.contributor.authorStein, Dan J.
dc.contributor.authorToga, Arthur W.
dc.contributor.authorTrollor, Julian N.
dc.contributor.authorVan der Wee, Nic J.A.
dc.contributor.authorvan't Ent, Dennis
dc.contributor.authorVölzke, Henry
dc.contributor.authorWalter, Henrik
dc.contributor.authorWeber, Bernd
dc.contributor.authorWeinberger, Daniel R.
dc.contributor.authorWright, Margaret J.
dc.contributor.authorZhou, Juan
dc.contributor.authorStein, Jason L.
dc.contributor.authorThompson, Paul M.
dc.contributor.authorMedland, Sarah E.
dc.contributor.departmentRadiology and Imaging Sciences, School of Medicineen_US
dc.date.accessioned2022-07-11T16:45:47Z
dc.date.available2022-07-11T16:45:47Z
dc.date.issued2020-03-20
dc.description.abstractThe cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.en_US
dc.eprint.versionAuthor's manuscripten_US
dc.identifier.citationGrasby KL, Jahanshad N, Painter JN, et al. The genetic architecture of the human cerebral cortex [published correction appears in Science. 2021 Oct 22;374(6566):eabm7211]. Science. 2020;367(6484):eaay6690. doi:10.1126/science.aay6690en_US
dc.identifier.urihttps://hdl.handle.net/1805/29520
dc.language.isoen_USen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.relation.isversionof10.1126/science.aay6690en_US
dc.relation.journalScienceen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectAttention Deficit Disorder with Hyperactivityen_US
dc.subjectCerebral Cortexen_US
dc.subjectGenome-Wide Association Studyen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.titleThe Genetic Architecture of the Human Cerebral Cortexen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
nihms-1586184.pdf
Size:
2.6 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.99 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Access Policy Articles
Department of Radiology and Imaging Sciences Works