Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer

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dc.contributor.authorLoi, Sherene
dc.contributor.authorSalgado, Roberto
dc.contributor.authorAdams, Sylvia
dc.contributor.authorPruneri, Giancarlo
dc.contributor.authorFrancis, Prudence A.
dc.contributor.authorLacroix-Triki, Magali
dc.contributor.authorJoensuu, Heikki
dc.contributor.authorDieci, Maria Vittoria
dc.contributor.authorBadve, Sunil
dc.contributor.authorDemaria, Sandra
dc.contributor.authorGray, Robert
dc.contributor.authorMunzone, Elisabetta
dc.contributor.authorDrubay, Damien
dc.contributor.authorLemonnier, Jerome
dc.contributor.authorSotiriou, Christos
dc.contributor.authorKellokumpu-Lehtinen, Pirkko Liisa
dc.contributor.authorVingiani, Andrea
dc.contributor.authorGray, Kathryn
dc.contributor.authorAndré, Fabrice
dc.contributor.authorDenkert, Carsten
dc.contributor.authorPiccart, Martine
dc.contributor.authorRoblin, Elvire
dc.contributor.authorMichiels, Stefan
dc.contributor.departmentPathology and Laboratory Medicine, School of Medicine
dc.date.accessioned2024-04-30T11:54:43Z
dc.date.available2024-04-30T11:54:43Z
dc.date.issued2022-01-11
dc.description.abstractThe importance of integrating biomarkers into the TNM staging has been emphasized in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8th edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs.
dc.eprint.versionFinal published version
dc.identifier.citationLoi S, Salgado R, Adams S, et al. Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer. NPJ Breast Cancer. 2022;8(1):3. Published 2022 Jan 11. doi:10.1038/s41523-021-00362-1
dc.identifier.urihttps://hdl.handle.net/1805/40354
dc.language.isoen_US
dc.publisherSpringer Nature
dc.relation.isversionof10.1038/s41523-021-00362-1
dc.relation.journalNPJ Breast Cancer
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourcePMC
dc.subjectBreast cancer
dc.subjectPrognostic markers
dc.titleTumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer
dc.typeArticle
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