Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses
dc.contributor.author | Lewis, Joshua E. | |
dc.contributor.author | Singh, Naveen | |
dc.contributor.author | Holmila, Reetta J. | |
dc.contributor.author | Sumer, Baran D. | |
dc.contributor.author | Williams, Noelle S. | |
dc.contributor.author | Furdui, Cristina M. | |
dc.contributor.author | Kemp, Melissa L. | |
dc.contributor.author | Boothman, David A. | |
dc.contributor.department | Biochemistry and Molecular Biology, School of Medicine | en_US |
dc.date.accessioned | 2020-03-02T19:32:19Z | |
dc.date.available | 2020-03-02T19:32:19Z | |
dc.date.issued | 2019-01 | |
dc.description.abstract | Nicotinamide adenine dinucleotide (NAD+) metabolism is integrally connected with the mechanisms of action of radiation therapy and is altered in many radiation-resistant tumors. This makes NAD+ metabolism an ideal target for therapies that increase radiation sensitivity and improve patient outcomes. This review provides an overview of NAD+ metabolism in the context of the cellular response to ionizing radiation, as well as current therapies that target NAD+ metabolism to enhance radiation therapy responses. Additionally, we summarize state-of-the-art methods for measuring, modeling, and manipulating NAD+ metabolism, which are being used to identify novel targets in the NAD+ metabolic network for therapeutic interventions in combination with radiation therapy. | en_US |
dc.eprint.version | Author's manuscript | en_US |
dc.identifier.citation | Lewis, J. E., Singh, N., Holmila, R. J., Sumer, B. D., Williams, N. S., Furdui, C. M., ... & Boothman, D. A. (2019, January). Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses. In Seminars in radiation oncology (Vol. 29, No. 1, pp. 6-15). WB Saunders. 10.1016/j.semradonc.2018.10.009 | en_US |
dc.identifier.issn | 1053-4296 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/22203 | |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.isversionof | 10.1016/j.semradonc.2018.10.009 | en_US |
dc.relation.journal | Seminars in Radiation Oncology | en_US |
dc.rights | Publisher Policy | en_US |
dc.source | PMC | en_US |
dc.subject | Nicotinamide adenine dinucleotide (NAD+) | en_US |
dc.subject | Nicotinamide adenine dinucleotide (NAD+) metabolism | en_US |
dc.subject | Radiation therapy | en_US |
dc.title | Targeting NAD+ Metabolism to Enhance Radiation Therapy Responses | en_US |
dc.type | Article | en_US |