Parathyroid Carcinoma: Incidence, Survival Analysis, and Management: A Study from the SEER Database and Insights into Future Therapeutic Perspectives
dc.contributor.author | Ullah, Asad | |
dc.contributor.author | Khan, Jaffar | |
dc.contributor.author | Waheed, Abdul | |
dc.contributor.author | Sharma, Nitasha | |
dc.contributor.author | Pryor, Elizabeth K. | |
dc.contributor.author | Stumpe, Tanner R. | |
dc.contributor.author | Velasquez Zarate, Luis | |
dc.contributor.author | Cason, Frederick D. | |
dc.contributor.author | Kumar, Suresh | |
dc.contributor.author | Misra, Subhasis | |
dc.contributor.author | Kavuri, Sravan | |
dc.contributor.author | Mesa, Hector | |
dc.contributor.author | Roper, Nitin | |
dc.contributor.author | Foroutan, Shahin | |
dc.contributor.author | Karki, Nabin Raj | |
dc.contributor.author | Del Rivero, Jaydira | |
dc.contributor.author | Simonds, William F. | |
dc.contributor.author | Karim, Nagla Abdel | |
dc.contributor.department | Pathology and Laboratory Medicine, School of Medicine | en_US |
dc.date.accessioned | 2023-05-18T11:35:43Z | |
dc.date.available | 2023-05-18T11:35:43Z | |
dc.date.issued | 2022-03-10 | |
dc.description.abstract | Introduction: Parathyroid carcinoma (PC) is an extremely rare entity, with a frequency of 0.005% of all malignancies. Most data related to this rare disease are limited to case series and a few database studies. We present a large database study that aims to investigate the demographic, clinical, and pathological factors, prognosis, and survival of PC. Methods: Data of parathyroid carcinoma were extracted from the Surveillance, Epidemiology, and End Results (SEER) diagnosed between 1975 and 2016. Results: PC had a slightly higher incidence in men (52.2%, p < 0.005), the majority of cases affected Caucasians (75.4%, p < 0.005), and the mean age at diagnosis was 62 years. Histologically, 99.7% were adenocarcinomas not otherwise specified (p < 0.005), well-differentiated (p < 0.005), and 2−4 cm (p < 0.001) in size among the patients with available data. In cases with staging provided, most PC were organ-confined (36.8%, p < 0.001). Lymph nodes were positive in 25.2% of cases where lymph node status was reported. The main treatment modality was surgery (97.2%), followed by radiation alone (2%), and very few received chemotherapy alone (0.8%), p < 0.005. Five-year follow-up was available for 82.7% of the cases. Those who underwent surgery only or radiation alone had 5-year survivals of 83.8% and 72.2%, respectively (p < 0.037). Multivariable analysis identified tumor size >4 cm, age > 40 years, male sex, Caucasian race, distant spread, and poorly differentiated grade as independent risk factors for mortality (p < 0.001). Conclusion: PC is a very rare tumor mostly affecting Caucasian individuals in the fifth decade. Older age, poor histologic differentiation, and distant metastasis are associated with a worse prognosis. Surgical resection offers the best survival outcome. To better understand the pathogenesis and factors affecting survival, all PC patients should be enrolled in national and international registries. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Ullah A, Khan J, Waheed A, et al. Parathyroid Carcinoma: Incidence, Survival Analysis, and Management: A Study from the SEER Database and Insights into Future Therapeutic Perspectives. Cancers (Basel). 2022;14(6):1426. Published 2022 Mar 10. doi:10.3390/cancers14061426 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/33092 | |
dc.language.iso | en_US | en_US |
dc.publisher | MDPI | en_US |
dc.relation.isversionof | 10.3390/cancers14061426 | en_US |
dc.relation.journal | Cancers | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | PMC | en_US |
dc.subject | SEER program | en_US |
dc.subject | Cancer staging | en_US |
dc.subject | Incidence | en_US |
dc.subject | Mortality | en_US |
dc.subject | Parathyroid carcinoma | en_US |
dc.subject | Survival | en_US |
dc.title | Parathyroid Carcinoma: Incidence, Survival Analysis, and Management: A Study from the SEER Database and Insights into Future Therapeutic Perspectives | en_US |
dc.type | Article | en_US |