Does Graded Prognostic Assessment outperform Recursive Partitioning Analysis in patients with moderate prognosis brain metastases?

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dc.contributor.authorEstabrook, Neil C.
dc.contributor.authorLutz, Stephen T.
dc.contributor.authorJohnson, Cynthia S.
dc.contributor.authorLo, Simon S.
dc.contributor.authorHenderson, Mark A.
dc.contributor.departmentRadiation Oncology, School of Medicineen_US
dc.date.accessioned2019-05-24T19:57:48Z
dc.date.available2019-05-24T19:57:48Z
dc.date.issued2016
dc.description.abstractAIM: To compare the clinical utility of the Recursive Partitioning Analysis (RPA) and Graded Prognostic Assessment (GPA) in predicting outcomes for moderate prognosis patients with brain metastases. METHODS & MATERIALS: We reviewed 101 whole brain radiotherapy cases. RPA and GPA were calculated. Overall survival was compared. RESULTS: Sixty-eight patients had moderate prognosis. RPA patient characteristics for increased death hazard were ≤10 WBRT fractions or no surgery/radiosurgery. GPA patients had increased death risk with no surgery/radiosurgery or lower Karnofsky Performance Status. CONCLUSION: The indices have similar predicted survival. Patients scored by RPA with longer radiation schedules had longer survival; patients scored by GPA did not. This indicates GPA is more clinically useful, leaving less room for subjective treatment choices.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationEstabrook, N. C., Lutz, S. T., Johnson, C. S., Lo, S. S., & Henderson, M. A. (2016). Does Graded Prognostic Assessment outperform Recursive Partitioning Analysis in patients with moderate prognosis brain metastases?. CNS oncology, 5(2), 69–76. doi:10.2217/cns.15.45en_US
dc.identifier.urihttps://hdl.handle.net/1805/19478
dc.language.isoen_USen_US
dc.publisherFuture Medicineen_US
dc.relation.isversionof10.2217/cns.15.45en_US
dc.relation.journalCNS Oncologyen_US
dc.rightsPublisher Policyen_US
dc.sourcePMCen_US
dc.subjectBrain metastasisen_US
dc.subjectPrognosisen_US
dc.subjectRadiotherapyen_US
dc.titleDoes Graded Prognostic Assessment outperform Recursive Partitioning Analysis in patients with moderate prognosis brain metastases?en_US
dc.typeArticleen_US
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