Assessment of folate receptor-β expression in human neoplastic tissues
dc.contributor.author | Shen, Jiayin | |
dc.contributor.author | Putt, Karson S. | |
dc.contributor.author | Visscher, Daniel W. | |
dc.contributor.author | Murphy, Linda | |
dc.contributor.author | Cohen, Cynthia | |
dc.contributor.author | Singhal, Sunil | |
dc.contributor.author | Sandusky, George | |
dc.contributor.author | Feng, Yang | |
dc.contributor.author | Dimitrov, Dimiter S. | |
dc.contributor.author | Low, Philip S. | |
dc.contributor.department | Department of Pathology & Laboratory Medicine, IU School of Medicine | en_US |
dc.date.accessioned | 2016-09-16T15:47:21Z | |
dc.date.available | 2016-09-16T15:47:21Z | |
dc.date.issued | 2015-06-10 | |
dc.description.abstract | Over-expression of folate receptor alpha on cancer cells has been frequently exploited for delivery of folate-targeted imaging and therapeutic agents to tumors. Because limited information exists on expression of the beta isoform of the folate receptor in human cancers (FR-β), we have evaluated the immunohistochemical staining pattern of FR-β in 992 tumor sections from 20 different human cancer types using a new anti-human FR-β monoclonal antibody. FR-β expression was shown to be more pronounced in cells within the stroma, primarily macrophages and macrophage-like cells than cancer cells in every cancer type studied. Moreover, FR-β expression in both cancer and stromal cells was found to be statistically more prominent in females than males. A significant positive correlation was also observed between FR-β expression on stromal cells and both the stage of the cancer and the presence of lymph node metastases. Based on these data we conclude FR-β may constitute a good target for specific delivery of therapeutic agents to activated macrophages and that accumulation of FR-β positive macrophages in the stroma could serve as a useful indicator of a tumor's metastatic potential. | en_US |
dc.eprint.version | Final published version | en_US |
dc.identifier.citation | Shen, J., Putt, K. S., Visscher, D. W., Murphy, L., Cohen, C., Singhal, S., … Low, P. S. (2015). Assessment of folate receptor-β expression in human neoplastic tissues. Oncotarget, 6(16), 14700–14709. | en_US |
dc.identifier.issn | 1949-2553 | en_US |
dc.identifier.uri | https://hdl.handle.net/1805/10955 | |
dc.language.iso | en_US | en_US |
dc.publisher | Impact Journals, LLC | en_US |
dc.relation.isversionof | 10.18632/oncotarget.3739 | en_US |
dc.relation.journal | Oncotarget | en_US |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | PMC | en_US |
dc.subject | Folate Receptor 2 | en_US |
dc.subject | metabolism | en_US |
dc.subject | Macrophages | en_US |
dc.subject | Neoplasms | en_US |
dc.title | Assessment of folate receptor-β expression in human neoplastic tissues | en_US |
dc.type | Article | en_US |
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