Highly sensitive lipid detection and localization in atherosclerotic plaque with a dual-frequency intravascular photoacoustic/ultrasound catheter
dc.contributor.author | Cao, Yingchun | |
dc.contributor.author | Alloosh, Mouhamad | |
dc.contributor.author | Sturek, Michael | |
dc.contributor.author | Cheng, Ji-Xin | |
dc.contributor.department | Anatomy, Cell Biology and Physiology, School of Medicine | |
dc.date.accessioned | 2024-03-08T10:26:18Z | |
dc.date.available | 2024-03-08T10:26:18Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Intravascular photoacoustic/ultrasound (IVPA/US) is an emerging hybrid imaging modality that provides specific lipid detection and localization, while maintaining co-registered artery morphology, for diagnosis of vulnerable plaque in cardiovascular disease. However, current IVPA/US approaches based on a single-element transducer exhibit compromised performance for lipid detection due to the relatively low contrast of lipid absorption and conflicting detection bands for photoacoustic and ultrasound signals. Here, we present a dual-frequency IVPA/US catheter for highly sensitive detection and precision localization of lipids. The low frequency transducer provides enhanced photoacoustic sensitivity, while the high frequency transducer maintains state-of-the-art spatial resolution for ultrasound imaging. The boosted capability of IVPA/US imaging enables a multi-scale analysis of lipid distribution in swine with coronary atherosclerosis. The dual-frequency IVPA/US catheter has a diameter of 1 mm and flexibility to easily adapt to current catheterization procedures and is a significant step toward clinical diagnosis of vulnerable plaque. | |
dc.eprint.version | Author's manuscript | |
dc.identifier.citation | Cao Y, Alloosh M, Sturek M, Cheng JX. Highly sensitive lipid detection and localization in atherosclerotic plaque with a dual-frequency intravascular photoacoustic/ultrasound catheter. Transl Biophotonics. 2020;2(3):e202000004. doi:10.1002/tbio.202000004 | |
dc.identifier.uri | https://hdl.handle.net/1805/39103 | |
dc.language.iso | en_US | |
dc.publisher | Wiley | |
dc.relation.isversionof | 10.1002/tbio.202000004 | |
dc.relation.journal | Translational Biophotonics | |
dc.rights | Publisher Policy | |
dc.source | PMC | |
dc.subject | Atherosclerotic plaque | |
dc.subject | Dual-frequency | |
dc.subject | Intravascular photoacoustic | |
dc.subject | Lipid core | |
dc.subject | Ossabaw miniature swine | |
dc.title | Highly sensitive lipid detection and localization in atherosclerotic plaque with a dual-frequency intravascular photoacoustic/ultrasound catheter | |
dc.type | Article |