The Dynamic Interplay Between Mast Cells, Aging/Cellular Senescence, and Liver Disease

dc.contributor.authorKundu, Debjyoti
dc.contributor.authorKennedy, Lindsey
dc.contributor.authorMeadows, Vik
dc.contributor.authorBaiocchi, Leonardo
dc.contributor.authorAlpini, Gianfranco
dc.contributor.authorFrancis, Heather
dc.contributor.departmentMedicine, School of Medicineen_US
dc.date.accessioned2022-01-12T22:12:54Z
dc.date.available2022-01-12T22:12:54Z
dc.date.issued2020-11
dc.description.abstractMast cells are key players in acute immune responses that are evidenced by degranulation leading to a heightened allergic response. Activation of mast cells can trigger a number of different pathways contributing to metabolic conditions and disease progression. Aging results in irreversible physiological changes affecting all organs, including the liver. The liver undergoes senescence, changes in protein expression, and cell signaling phenotypes during aging, which regulate disease progression. Cellular senescence contributes to the age-related changes. Unsurprisingly, mast cells also undergo age-related changes in number, localization, and activation throughout their lifetime, which adversely affects the etiology and progression of many physiological conditions including liver diseases. In this review, we discuss the role of mast cells during aging, including features of aging (e.g., senescence) in the context of biliary diseases such as primary biliary cholangitis and primary sclerosing cholangitis and nonalcoholic fatty liver disease.en_US
dc.eprint.versionFinal published versionen_US
dc.identifier.citationKundu, D., Kennedy, L., Meadows, V., Baiocchi, L., Alpini, G., & Francis, H. (2020). The Dynamic Interplay Between Mast Cells, Aging/Cellular Senescence, and Liver Disease. Gene Expression, 20(2), 77–88. https://doi.org/10.3727/105221620X15960509906371en_US
dc.identifier.issn1052-2166en_US
dc.identifier.urihttps://hdl.handle.net/1805/27414
dc.language.isoen_USen_US
dc.publisherCognizant Communication Corporationen_US
dc.relation.isversionof10.3727/105221620X15960509906371en_US
dc.relation.journalGene Expressionen_US
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0*
dc.sourcePublisheren_US
dc.subjectSenescenceen_US
dc.subjectSenescence-associated secretory phenotype (SASP)en_US
dc.subjectAgingen_US
dc.subjectMast cells (MCs)en_US
dc.subjectLiver diseasesen_US
dc.subjectInflammationen_US
dc.subjectFibrosisen_US
dc.titleThe Dynamic Interplay Between Mast Cells, Aging/Cellular Senescence, and Liver Diseaseen_US
dc.typeArticleen_US
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