Effects of GSK3-β Inhibitors on Wnt Signaling in Zebrafish Fin Regeneration: Chemical Biology

dc.contributor.authorBrannick, Angelica
dc.contributor.authorMahin, Jennifer L.
dc.contributor.authorFarrel, Mark
dc.contributor.authorCurtis, Courtney
dc.contributor.authorSarmah, Swapnalee
dc.contributor.authorCollins, Kayla
dc.contributor.authorChu, Shaoyou
dc.contributor.authorSato, Mas
dc.contributor.authorSanchez-Felix, Manuel
dc.date.accessioned2014-04-14T21:31:56Z
dc.date.available2014-04-14T21:31:56Z
dc.date.issued2014-04-11
dc.description.abstractIn order to develop beneficial drugs for osteoporosis it is important to understand the molecular mechanisms of bone regeneration and define specific regulatory factors. Zebrafish can regenerate damaged tissues, and they prove to be a good model to study bone growth and repair. Previous research showed that GSK3β inhibitor compound at various concentrations and for different treatment periods effectively stimulated fin regeneration. Conducted experiments identified temporal and spatial fluctuations on individual gene markers after GSK3β inhibitor treatment at various concentrations. Recent analyzed data uses the Lilly Research Labs experimental compound LSN 2105786 at 3 nM and 5 nM to stimulate tissue regeneration to determine whether activating Wnt signaling produces cell proliferation and β-catenin translocation to the nucleus for zebrafish bone regeneration. This research has potential to identify mechanism of bone growth and repair, leading to more suitable drugs for patients suffering with osteoporosis.en_US
dc.description.sponsorshipThis work was supported by a research grant from Lilly Research Labs. Angelica Brannick and Jennifer Mahin were supported by the IUPUI UROP/CRL program.en_US
dc.identifier.citationBrannick, A., Mahin, J.L., Farrel, M., Curtis, C., Sarmah, S., Collins, K., ... Marrs, J.A. (2014, April 11). Effects of GSK3-β inhibitors on Wnt signaling in zebrafish fin regeneration: Chemical biology. Poster session presented at IUPUI Research Day 2014, Indianapolis, Indiana.en_US
dc.identifier.urihttps://hdl.handle.net/1805/4259
dc.language.isoen_USen_US
dc.subject.lcshOsteoporosisen_US
dc.subject.lcshZebrafishen_US
dc.subject.lcshBone regenerationen_US
dc.titleEffects of GSK3-β Inhibitors on Wnt Signaling in Zebrafish Fin Regeneration: Chemical Biologyen_US
dc.typePresentationen_US
Files
Original bundle
Now showing 1 - 2 of 2
Loading...
Thumbnail Image
Name:
brannick-2014-effects.pdf
Size:
2.7 MB
Format:
Adobe Portable Document Format
Description:
Poster
Loading...
Thumbnail Image
Name:
brannick-b104.pdf
Size:
39.84 KB
Format:
Adobe Portable Document Format
Description:
Abstract
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.88 KB
Format:
Item-specific license agreed upon to submission
Description: